Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

Plant homeodomain fingers (PHD-fingers) are a family of reader domains that can recruit epigenetic proteins to specific histone modification sites. Many PHD-fingers recognise methylated lysines on histone tails and play crucial roles in transcriptional regulation, with their dysregulation linked to...

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Detalles Bibliográficos
Autores principales: Coleman, Oliver D., Macdonald, Jessica, Thomson, Ben, Ward, Jennifer A., Stubbs, Christopher J., McAllister, Tom E., Clark, Shane, Amin, Siddique, Cao, Yimang, Abboud, Martine I., Zhang, Yijia, Sanganee, Hitesh, Huber, Kilian V. M., Claridge, Tim D. W., Kawamura, Akane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321576/
https://www.ncbi.nlm.nih.gov/pubmed/37416723
http://dx.doi.org/10.1039/d2sc05944d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321576/
https://www.ncbi.nlm.nih.gov/pubmed/37416723
http://dx.doi.org/10.1039/d2sc05944d

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