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Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients

BACKGROUND: Remnant cholesterol (RC) and chronic kidney disease (CKD) have not been definitively linked in individuals with different characteristics. This study aims to investigate the relationship between serum RC level and CKD and examine possible effect modifiers in Chinese patients with hyperte...

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Autores principales: Yuan, Ting, Ding, Congcong, Xie, Yanyou, Zhou, Xinlei, Xie, Chong, Wang, Tao, Yu, Chao, Zhou, Wei, Zhu, Lingjuan, Bao, Huihui, Cheng, Xiaoshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321593/
https://www.ncbi.nlm.nih.gov/pubmed/37415665
http://dx.doi.org/10.3389/fendo.2023.1189574
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author Yuan, Ting
Ding, Congcong
Xie, Yanyou
Zhou, Xinlei
Xie, Chong
Wang, Tao
Yu, Chao
Zhou, Wei
Zhu, Lingjuan
Bao, Huihui
Cheng, Xiaoshu
author_facet Yuan, Ting
Ding, Congcong
Xie, Yanyou
Zhou, Xinlei
Xie, Chong
Wang, Tao
Yu, Chao
Zhou, Wei
Zhu, Lingjuan
Bao, Huihui
Cheng, Xiaoshu
author_sort Yuan, Ting
collection PubMed
description BACKGROUND: Remnant cholesterol (RC) and chronic kidney disease (CKD) have not been definitively linked in individuals with different characteristics. This study aims to investigate the relationship between serum RC level and CKD and examine possible effect modifiers in Chinese patients with hypertension. METHODS: Our study is based on the Chinese H-type Hypertension Project, which is an observational registry study conducted in real-world settings. The outcome was CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min·1.73 m(2). Multivariate logistic regression and smooth curve fitting were used to analyze the association between RC and CKD. Subgroup analyses were subsequently conducted to examine the effects of other variables. RESULTS: The mean age of the 13,024 patients with hypertension at baseline was 63.8 ± 9.4 years, and 46.8% were male. A conspicuous linear positive association was observed between RC level and CKD (per SD increment; odds ratio [OR], 1.15; 95% confidence interval [CI], 1.08–1.23). Compared with the lowest quartile group of RC, the risk of CKD was 53% higher (OR, 1.53; 95% CI, 1.26–1.86) in the highest quartile group. Furthermore, a stronger positive association between RC level and CKD was found among participants with a higher body mass index (BMI <24 vs. ≥24 kg/m(2); P-interaction = 0.034) or current non-smokers (smoker vs. non-smoker; P-interaction = 0.024). CONCLUSIONS: Among Chinese adults with hypertension, RC level was positively associated with CKD, particularly in those with a BMI of ≥24 kg/m(2) and current non-smokers. These findings may help improve lipid management regimens in patients with hypertension.
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spelling pubmed-103215932023-07-06 Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients Yuan, Ting Ding, Congcong Xie, Yanyou Zhou, Xinlei Xie, Chong Wang, Tao Yu, Chao Zhou, Wei Zhu, Lingjuan Bao, Huihui Cheng, Xiaoshu Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Remnant cholesterol (RC) and chronic kidney disease (CKD) have not been definitively linked in individuals with different characteristics. This study aims to investigate the relationship between serum RC level and CKD and examine possible effect modifiers in Chinese patients with hypertension. METHODS: Our study is based on the Chinese H-type Hypertension Project, which is an observational registry study conducted in real-world settings. The outcome was CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min·1.73 m(2). Multivariate logistic regression and smooth curve fitting were used to analyze the association between RC and CKD. Subgroup analyses were subsequently conducted to examine the effects of other variables. RESULTS: The mean age of the 13,024 patients with hypertension at baseline was 63.8 ± 9.4 years, and 46.8% were male. A conspicuous linear positive association was observed between RC level and CKD (per SD increment; odds ratio [OR], 1.15; 95% confidence interval [CI], 1.08–1.23). Compared with the lowest quartile group of RC, the risk of CKD was 53% higher (OR, 1.53; 95% CI, 1.26–1.86) in the highest quartile group. Furthermore, a stronger positive association between RC level and CKD was found among participants with a higher body mass index (BMI <24 vs. ≥24 kg/m(2); P-interaction = 0.034) or current non-smokers (smoker vs. non-smoker; P-interaction = 0.024). CONCLUSIONS: Among Chinese adults with hypertension, RC level was positively associated with CKD, particularly in those with a BMI of ≥24 kg/m(2) and current non-smokers. These findings may help improve lipid management regimens in patients with hypertension. Frontiers Media S.A. 2023-06-21 /pmc/articles/PMC10321593/ /pubmed/37415665 http://dx.doi.org/10.3389/fendo.2023.1189574 Text en Copyright © 2023 Yuan, Ding, Xie, Zhou, Xie, Wang, Yu, Zhou, Zhu, Bao and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yuan, Ting
Ding, Congcong
Xie, Yanyou
Zhou, Xinlei
Xie, Chong
Wang, Tao
Yu, Chao
Zhou, Wei
Zhu, Lingjuan
Bao, Huihui
Cheng, Xiaoshu
Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients
title Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients
title_full Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients
title_fullStr Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients
title_full_unstemmed Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients
title_short Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients
title_sort association between remnant cholesterol and chronic kidney disease in chinese hypertensive patients
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321593/
https://www.ncbi.nlm.nih.gov/pubmed/37415665
http://dx.doi.org/10.3389/fendo.2023.1189574
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