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Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis

BACKGROUND: Toxoplasmosis is one of the most common infections in humans and animals, which is caused by an obligate intracellular opportunistic parasite known as Toxoplasma gondii (T. gondii). Some data have shown that both Rhesus (Rh)-positive and Rh-negative individuals differ in response to biol...

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Autores principales: Nayeri, Tooran, Moosazadeh, Mahmood, Asl, Abdolhossein Dalimi, Ghaffarifar, Fatemeh, Sarvi, Shahabeddin, Daryani, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321609/
https://www.ncbi.nlm.nih.gov/pubmed/37406027
http://dx.doi.org/10.1371/journal.pone.0287992
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author Nayeri, Tooran
Moosazadeh, Mahmood
Asl, Abdolhossein Dalimi
Ghaffarifar, Fatemeh
Sarvi, Shahabeddin
Daryani, Ahmad
author_facet Nayeri, Tooran
Moosazadeh, Mahmood
Asl, Abdolhossein Dalimi
Ghaffarifar, Fatemeh
Sarvi, Shahabeddin
Daryani, Ahmad
author_sort Nayeri, Tooran
collection PubMed
description BACKGROUND: Toxoplasmosis is one of the most common infections in humans and animals, which is caused by an obligate intracellular opportunistic parasite known as Toxoplasma gondii (T. gondii). Some data have shown that both Rhesus (Rh)-positive and Rh-negative individuals differ in response to biological factors, including Toxoplasma infection. Therefore, this systematic review and meta-analysis was conducted to investigate the scientific evidence regarding the possible association between the Rh blood group and Toxoplasma infection and to determine the seroprevalence of T. gondii in the Rh blood group system. METHODS: The research was conducted on PubMed, ScienceDirect, ProQuest, and Google Scholar databases until January 2023. Twenty-one cross-sectional studies were included with a total of 10910 people. The data were synthesized using a random effect model with 95% confidence intervals (CIs). RESULTS: The overall prevalence of T. gondii was calculated at 32.34% (CI 95%: 28.23–36.45%) and 33.35% (CI 95%: 19.73–46.96%) in Rh-positive and Rh-negative blood groups. In addition, the pooled OR for the relationship between the Rh blood group and the seroprevalence of T. gondii was 0.96 (95% CI: 0.72–1.28). CONCLUSIONS: This meta-analysis showed a high prevalence of Toxoplasma infection in both Rh-negative and positive blood groups. This systematic review and meta-analysis revealed that no significant association was found between toxoplasmosis and Rh factor. Because of the limited number of studies in this field, more research is recommended to determine the exact relationship between toxoplasmosis and the Rh factor.
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spelling pubmed-103216092023-07-06 Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis Nayeri, Tooran Moosazadeh, Mahmood Asl, Abdolhossein Dalimi Ghaffarifar, Fatemeh Sarvi, Shahabeddin Daryani, Ahmad PLoS One Research Article BACKGROUND: Toxoplasmosis is one of the most common infections in humans and animals, which is caused by an obligate intracellular opportunistic parasite known as Toxoplasma gondii (T. gondii). Some data have shown that both Rhesus (Rh)-positive and Rh-negative individuals differ in response to biological factors, including Toxoplasma infection. Therefore, this systematic review and meta-analysis was conducted to investigate the scientific evidence regarding the possible association between the Rh blood group and Toxoplasma infection and to determine the seroprevalence of T. gondii in the Rh blood group system. METHODS: The research was conducted on PubMed, ScienceDirect, ProQuest, and Google Scholar databases until January 2023. Twenty-one cross-sectional studies were included with a total of 10910 people. The data were synthesized using a random effect model with 95% confidence intervals (CIs). RESULTS: The overall prevalence of T. gondii was calculated at 32.34% (CI 95%: 28.23–36.45%) and 33.35% (CI 95%: 19.73–46.96%) in Rh-positive and Rh-negative blood groups. In addition, the pooled OR for the relationship between the Rh blood group and the seroprevalence of T. gondii was 0.96 (95% CI: 0.72–1.28). CONCLUSIONS: This meta-analysis showed a high prevalence of Toxoplasma infection in both Rh-negative and positive blood groups. This systematic review and meta-analysis revealed that no significant association was found between toxoplasmosis and Rh factor. Because of the limited number of studies in this field, more research is recommended to determine the exact relationship between toxoplasmosis and the Rh factor. Public Library of Science 2023-07-05 /pmc/articles/PMC10321609/ /pubmed/37406027 http://dx.doi.org/10.1371/journal.pone.0287992 Text en © 2023 Nayeri et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nayeri, Tooran
Moosazadeh, Mahmood
Asl, Abdolhossein Dalimi
Ghaffarifar, Fatemeh
Sarvi, Shahabeddin
Daryani, Ahmad
Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis
title Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis
title_full Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis
title_fullStr Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis
title_full_unstemmed Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis
title_short Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis
title_sort toxoplasma infection and rhesus blood group system: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321609/
https://www.ncbi.nlm.nih.gov/pubmed/37406027
http://dx.doi.org/10.1371/journal.pone.0287992
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