Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes

Pelger-Huët anomaly (PHA) in humans is an autosomal dominant hematological phenotype without major clinical consequences. PHA involves a characteristic hyposegmentation of granulocytes (HG). Human PHA is caused by heterozygous loss of function variants in the LBR gene encoding lamin receptor B. Bi-a...

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Detalles Bibliográficos
Autores principales: Lourdes Frehner, Bianca, Christen, Matthias, Reichler, Iris M., Jagannathan, Vidhya, Novacco, Marilisa, Riond, Barbara, Peters, Laureen M., Suárez Sánchez-Andrade, José, Pieńkowska-Schelling, Aldona, Schelling, Claude, Kipar, Anja, Leeb, Tosso, Balogh, Orsolya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321630/
https://www.ncbi.nlm.nih.gov/pubmed/37347778
http://dx.doi.org/10.1371/journal.pgen.1010805

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