The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody

We have previously demonstrated that KS-133 is a specific and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2). We have also shown that vasoactive intestinal peptide–VIPR2 signaling affects the polarity and activation of tumor-associated macrophages, which is another strategy fo...

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Detalles Bibliográficos
Autores principales: Sakamoto, Kotaro, Kittikulsuth, Wararat, Miyako, Eijiro, Steeve, Akumwami, Ishimura, Rika, Nakagawa, Shinsaku, Ago, Yukio, Nishiyama, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321640/
https://www.ncbi.nlm.nih.gov/pubmed/37405999
http://dx.doi.org/10.1371/journal.pone.0286651

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