Single-molecule visualization determines conformational substate ensembles in β-sheet–rich peptide fibrils

An understanding of protein conformational ensembles is essential for revealing the underlying mechanisms of interpeptide recognition and association. However, experimentally resolving multiple simultaneously existing conformational substates remains challenging. Here, we report the use of scanning...

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Detalles Bibliográficos
Autores principales: Zhang, Wenbo, Wang, Ruonan, Liu, Mingwei, Li, Shucong, Vokoun, Asher E., Deng, Weichen, Dupont, Robert L., Zhang, Feiyi, Li, Shuyuan, Wang, Yang, Liu, Zhenyu, Zheng, Yongfang, Liu, Shuli, Yang, Yanlian, Wang, Chen, Yu, Lanlan, Yao, Yuxing, Wang, Xiaoguang, Wang, Chenxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321740/
https://www.ncbi.nlm.nih.gov/pubmed/37406110
http://dx.doi.org/10.1126/sciadv.adg7943

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