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Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology

Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extractio...

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Autores principales: Chen, Zhiyuan, Lin, Zexu, Obaid, Sofian N., Rytkin, Eric, George, Sharon A., Bach, Christopher, Madrid, Micah, Liu, Miya, LaPiano, Jessica, Fehr, Amy, Shi, Xinyu, Quirion, Nathaniel, Russo, Benjamin, Knight, Helen, Aduwari, Anthony, Efimov, Igor R., Lu, Luyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321742/
https://www.ncbi.nlm.nih.gov/pubmed/37406128
http://dx.doi.org/10.1126/sciadv.adi0757
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author Chen, Zhiyuan
Lin, Zexu
Obaid, Sofian N.
Rytkin, Eric
George, Sharon A.
Bach, Christopher
Madrid, Micah
Liu, Miya
LaPiano, Jessica
Fehr, Amy
Shi, Xinyu
Quirion, Nathaniel
Russo, Benjamin
Knight, Helen
Aduwari, Anthony
Efimov, Igor R.
Lu, Luyao
author_facet Chen, Zhiyuan
Lin, Zexu
Obaid, Sofian N.
Rytkin, Eric
George, Sharon A.
Bach, Christopher
Madrid, Micah
Liu, Miya
LaPiano, Jessica
Fehr, Amy
Shi, Xinyu
Quirion, Nathaniel
Russo, Benjamin
Knight, Helen
Aduwari, Anthony
Efimov, Igor R.
Lu, Luyao
author_sort Chen, Zhiyuan
collection PubMed
description Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.
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spelling pubmed-103217422023-07-06 Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology Chen, Zhiyuan Lin, Zexu Obaid, Sofian N. Rytkin, Eric George, Sharon A. Bach, Christopher Madrid, Micah Liu, Miya LaPiano, Jessica Fehr, Amy Shi, Xinyu Quirion, Nathaniel Russo, Benjamin Knight, Helen Aduwari, Anthony Efimov, Igor R. Lu, Luyao Sci Adv Physical and Materials Sciences Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement. American Association for the Advancement of Science 2023-07-05 /pmc/articles/PMC10321742/ /pubmed/37406128 http://dx.doi.org/10.1126/sciadv.adi0757 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Chen, Zhiyuan
Lin, Zexu
Obaid, Sofian N.
Rytkin, Eric
George, Sharon A.
Bach, Christopher
Madrid, Micah
Liu, Miya
LaPiano, Jessica
Fehr, Amy
Shi, Xinyu
Quirion, Nathaniel
Russo, Benjamin
Knight, Helen
Aduwari, Anthony
Efimov, Igor R.
Lu, Luyao
Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
title Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
title_full Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
title_fullStr Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
title_full_unstemmed Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
title_short Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
title_sort soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321742/
https://www.ncbi.nlm.nih.gov/pubmed/37406128
http://dx.doi.org/10.1126/sciadv.adi0757
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