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Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extractio...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321742/ https://www.ncbi.nlm.nih.gov/pubmed/37406128 http://dx.doi.org/10.1126/sciadv.adi0757 |
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author | Chen, Zhiyuan Lin, Zexu Obaid, Sofian N. Rytkin, Eric George, Sharon A. Bach, Christopher Madrid, Micah Liu, Miya LaPiano, Jessica Fehr, Amy Shi, Xinyu Quirion, Nathaniel Russo, Benjamin Knight, Helen Aduwari, Anthony Efimov, Igor R. Lu, Luyao |
author_facet | Chen, Zhiyuan Lin, Zexu Obaid, Sofian N. Rytkin, Eric George, Sharon A. Bach, Christopher Madrid, Micah Liu, Miya LaPiano, Jessica Fehr, Amy Shi, Xinyu Quirion, Nathaniel Russo, Benjamin Knight, Helen Aduwari, Anthony Efimov, Igor R. Lu, Luyao |
author_sort | Chen, Zhiyuan |
collection | PubMed |
description | Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement. |
format | Online Article Text |
id | pubmed-10321742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103217422023-07-06 Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology Chen, Zhiyuan Lin, Zexu Obaid, Sofian N. Rytkin, Eric George, Sharon A. Bach, Christopher Madrid, Micah Liu, Miya LaPiano, Jessica Fehr, Amy Shi, Xinyu Quirion, Nathaniel Russo, Benjamin Knight, Helen Aduwari, Anthony Efimov, Igor R. Lu, Luyao Sci Adv Physical and Materials Sciences Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement. American Association for the Advancement of Science 2023-07-05 /pmc/articles/PMC10321742/ /pubmed/37406128 http://dx.doi.org/10.1126/sciadv.adi0757 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Chen, Zhiyuan Lin, Zexu Obaid, Sofian N. Rytkin, Eric George, Sharon A. Bach, Christopher Madrid, Micah Liu, Miya LaPiano, Jessica Fehr, Amy Shi, Xinyu Quirion, Nathaniel Russo, Benjamin Knight, Helen Aduwari, Anthony Efimov, Igor R. Lu, Luyao Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
title | Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
title_full | Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
title_fullStr | Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
title_full_unstemmed | Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
title_short | Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
title_sort | soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321742/ https://www.ncbi.nlm.nih.gov/pubmed/37406128 http://dx.doi.org/10.1126/sciadv.adi0757 |
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