Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection

Semen is an important vector for sexual HIV-1 transmission. Although CXCR4-tropic (X4) HIV-1 may be present in semen, almost exclusively CCR5-tropic (R5) HIV-1 causes systemic infection after sexual intercourse. To identify factors that may limit sexual X4-HIV-1 transmission, we generated a seminal...

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Detalles Bibliográficos
Autores principales: Harms, Mirja, Smith, Nikaïa, Han, Mingyu, Groß, Rüdiger, von Maltitz, Pascal, Stürzel, Christina, Ruiz-Blanco, Yasser B., Almeida-Hernández, Yasser, Rodriguez-Alfonso, Armando, Cathelin, Dominique, Caspar, Birgit, Tahar, Bouceba, Sayettat, Sophie, Bekaddour, Nassima, Vanshylla, Kanika, Kleipass, Franziska, Wiese, Sebastian, Ständker, Ludger, Klein, Florian, Lagane, Bernard, Boonen, Arnaud, Schols, Dominique, Benichou, Serge, Sanchez-Garcia, Elsa, Herbeuval, Jean-Philippe, Münch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321752/
https://www.ncbi.nlm.nih.gov/pubmed/37406129
http://dx.doi.org/10.1126/sciadv.adf8251

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