Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function TP53 mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding p53 variant effects on tumorigenesis remains central...

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Detalles Bibliográficos
Autores principales: Chen, Jiangfei, Baxi, Kunal, Lipsitt, Amanda E, Hensch, Nicole Rae, Wang, Long, Sreenivas, Prethish, Modi, Paulomi, Zhao, Xiang Ru, Baudin, Antoine, Robledo, Daniel G, Bandyopadhyay, Abhik, Sugalski, Aaron, Challa, Anil K, Kurmashev, Dias, Gilbert, Andrea R, Tomlinson, Gail E, Houghton, Peter, Chen, Yidong, Hayes, Madeline N, Chen, Eleanor Y, Libich, David S, Ignatius, Myron S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322150/
https://www.ncbi.nlm.nih.gov/pubmed/37266578
http://dx.doi.org/10.7554/eLife.68221

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