Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases

OBJECTIVE: To analyze the clinical characteristics of neonatal infection during the outbreak of COVID-19 omicron variant in Guangdong province of China. METHOD: The clinical data of neonates infected with COVID-19 omicron variant were collected from three hospitals of Guangdong province, their epide...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yi-Kang, Lin, Fen, Lin, Jian-Feng, Lin, Chun-Fan, Liu, Li-Li, Ma, Yu-Bin, Wang, Xian-Yao, Liao, Yu-Wei, Huang, Yu-Chan, Zeng, Guang-Kuan, Xiao, Bei-Ru, Huang, Shan-Hua, Xu, Yu-Mei, Chen, Yue-E, Cao, Yan-Bin, Yang, Li-Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322182/
https://www.ncbi.nlm.nih.gov/pubmed/37416819
http://dx.doi.org/10.3389/fped.2023.1191651
_version_ 1785068697264586752
author Yang, Yi-Kang
Lin, Fen
Lin, Jian-Feng
Lin, Chun-Fan
Liu, Li-Li
Ma, Yu-Bin
Wang, Xian-Yao
Liao, Yu-Wei
Huang, Yu-Chan
Zeng, Guang-Kuan
Xiao, Bei-Ru
Huang, Shan-Hua
Xu, Yu-Mei
Chen, Yue-E
Cao, Yan-Bin
Yang, Li-Ye
author_facet Yang, Yi-Kang
Lin, Fen
Lin, Jian-Feng
Lin, Chun-Fan
Liu, Li-Li
Ma, Yu-Bin
Wang, Xian-Yao
Liao, Yu-Wei
Huang, Yu-Chan
Zeng, Guang-Kuan
Xiao, Bei-Ru
Huang, Shan-Hua
Xu, Yu-Mei
Chen, Yue-E
Cao, Yan-Bin
Yang, Li-Ye
author_sort Yang, Yi-Kang
collection PubMed
description OBJECTIVE: To analyze the clinical characteristics of neonatal infection during the outbreak of COVID-19 omicron variant in Guangdong province of China. METHOD: The clinical data of neonates infected with COVID-19 omicron variant were collected from three hospitals of Guangdong province, their epidemiological history, clinical manifestation and prognosis were summarized. RESULTS: From December 12, 2022 to January 15, 2023, a total of 52 neonates with COVID-19 infection were identified across three hospitals in Guangdong Province, including 34 males and 18 females. The age of diagnosis was 18.42 ± 6.32 days. 24 cases had clear contact history with adults who were suspected to be infected with COVID-19. The most common clinical manifestation was fever (43/52, 82.7%), the duration of fever was 1–8 days. The other clinical manifestations were cough (27/52, 51.9%), rales (21/52, 40.4%), nasal congestion (10/52, 19.2%), shortness of breath (2/52, 3.8%), and vomiting (4/52, 7.7%). C-reactive protein was only increased in 3 cases. Chest radiological examination was performed in 42 neonates, twenty-three cases showed abnormal chest radiographic findings, including ground-glass opacity and consolidation. Fifty cases were admitted with COVID-19 presentation, two cases were admitted for jaundice. The hospital stay was 6.59 ± 2.77 days. The clinical classification included 3 cases of severe COVID-19 and one critical case. Fifty-one cases were cured and discharged after general treatment, and one critical case with respiratory failure was intubated and transferred to another hospital. CONCLUSION: The COVID-19 omicron variant infection in neonates is usually mild. The clinical manifestation and laboratory results are not specific, and the short-term prognosis is good.
format Online
Article
Text
id pubmed-10322182
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103221822023-07-06 Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases Yang, Yi-Kang Lin, Fen Lin, Jian-Feng Lin, Chun-Fan Liu, Li-Li Ma, Yu-Bin Wang, Xian-Yao Liao, Yu-Wei Huang, Yu-Chan Zeng, Guang-Kuan Xiao, Bei-Ru Huang, Shan-Hua Xu, Yu-Mei Chen, Yue-E Cao, Yan-Bin Yang, Li-Ye Front Pediatr Pediatrics OBJECTIVE: To analyze the clinical characteristics of neonatal infection during the outbreak of COVID-19 omicron variant in Guangdong province of China. METHOD: The clinical data of neonates infected with COVID-19 omicron variant were collected from three hospitals of Guangdong province, their epidemiological history, clinical manifestation and prognosis were summarized. RESULTS: From December 12, 2022 to January 15, 2023, a total of 52 neonates with COVID-19 infection were identified across three hospitals in Guangdong Province, including 34 males and 18 females. The age of diagnosis was 18.42 ± 6.32 days. 24 cases had clear contact history with adults who were suspected to be infected with COVID-19. The most common clinical manifestation was fever (43/52, 82.7%), the duration of fever was 1–8 days. The other clinical manifestations were cough (27/52, 51.9%), rales (21/52, 40.4%), nasal congestion (10/52, 19.2%), shortness of breath (2/52, 3.8%), and vomiting (4/52, 7.7%). C-reactive protein was only increased in 3 cases. Chest radiological examination was performed in 42 neonates, twenty-three cases showed abnormal chest radiographic findings, including ground-glass opacity and consolidation. Fifty cases were admitted with COVID-19 presentation, two cases were admitted for jaundice. The hospital stay was 6.59 ± 2.77 days. The clinical classification included 3 cases of severe COVID-19 and one critical case. Fifty-one cases were cured and discharged after general treatment, and one critical case with respiratory failure was intubated and transferred to another hospital. CONCLUSION: The COVID-19 omicron variant infection in neonates is usually mild. The clinical manifestation and laboratory results are not specific, and the short-term prognosis is good. Frontiers Media S.A. 2023-06-20 /pmc/articles/PMC10322182/ /pubmed/37416819 http://dx.doi.org/10.3389/fped.2023.1191651 Text en © 2023 Yang, Lin, Lin, Lin, Liu, Ma, Wang, Liao, Huang, Zeng, Xiao, Huang, Xu, Chen, Cao and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yang, Yi-Kang
Lin, Fen
Lin, Jian-Feng
Lin, Chun-Fan
Liu, Li-Li
Ma, Yu-Bin
Wang, Xian-Yao
Liao, Yu-Wei
Huang, Yu-Chan
Zeng, Guang-Kuan
Xiao, Bei-Ru
Huang, Shan-Hua
Xu, Yu-Mei
Chen, Yue-E
Cao, Yan-Bin
Yang, Li-Ye
Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
title Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
title_full Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
title_fullStr Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
title_full_unstemmed Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
title_short Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
title_sort covid-19 omicron variant infection in neonates of guangdong province-a report of 52 cases
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322182/
https://www.ncbi.nlm.nih.gov/pubmed/37416819
http://dx.doi.org/10.3389/fped.2023.1191651
work_keys_str_mv AT yangyikang covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT linfen covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT linjianfeng covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT linchunfan covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT liulili covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT mayubin covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT wangxianyao covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT liaoyuwei covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT huangyuchan covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT zengguangkuan covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT xiaobeiru covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT huangshanhua covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT xuyumei covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT chenyuee covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT caoyanbin covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases
AT yangliye covid19omicronvariantinfectioninneonatesofguangdongprovinceareportof52cases