Cargando…

When blood pressure refuses to budge: exploring the complexity of resistant hypertension

Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite t...

Descripción completa

Detalles Bibliográficos
Autores principales: Champaneria, Meeti Keyur, Patel, Rushi Sanjaykumar, Oroszi, Terry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322223/
https://www.ncbi.nlm.nih.gov/pubmed/37416924
http://dx.doi.org/10.3389/fcvm.2023.1211199
_version_ 1785068705382662144
author Champaneria, Meeti Keyur
Patel, Rushi Sanjaykumar
Oroszi, Terry L.
author_facet Champaneria, Meeti Keyur
Patel, Rushi Sanjaykumar
Oroszi, Terry L.
author_sort Champaneria, Meeti Keyur
collection PubMed
description Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite the availability of a wide range of pharmacological therapies, achieving optimal blood pressure control in patients with resistant hypertension remains a significant challenge. However, recent advances in the field have identified several promising treatment options, including spironolactone, mineralocorticoid receptor antagonists, and renal denervation. In addition, personalized management approaches based on genetic and other biomarkers may offer new opportunities to tailor therapy and improve outcomes. This review aims to provide an overview of the current state of knowledge regarding managing resistant hypertension, including the epidemiology, pathophysiology, and clinical implications of the condition, as well as the latest developments in therapeutic strategies and future prospects.
format Online
Article
Text
id pubmed-10322223
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103222232023-07-06 When blood pressure refuses to budge: exploring the complexity of resistant hypertension Champaneria, Meeti Keyur Patel, Rushi Sanjaykumar Oroszi, Terry L. Front Cardiovasc Med Cardiovascular Medicine Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite the availability of a wide range of pharmacological therapies, achieving optimal blood pressure control in patients with resistant hypertension remains a significant challenge. However, recent advances in the field have identified several promising treatment options, including spironolactone, mineralocorticoid receptor antagonists, and renal denervation. In addition, personalized management approaches based on genetic and other biomarkers may offer new opportunities to tailor therapy and improve outcomes. This review aims to provide an overview of the current state of knowledge regarding managing resistant hypertension, including the epidemiology, pathophysiology, and clinical implications of the condition, as well as the latest developments in therapeutic strategies and future prospects. Frontiers Media S.A. 2023-06-21 /pmc/articles/PMC10322223/ /pubmed/37416924 http://dx.doi.org/10.3389/fcvm.2023.1211199 Text en © 2023 Champaneria, Patel and Oroszi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Champaneria, Meeti Keyur
Patel, Rushi Sanjaykumar
Oroszi, Terry L.
When blood pressure refuses to budge: exploring the complexity of resistant hypertension
title When blood pressure refuses to budge: exploring the complexity of resistant hypertension
title_full When blood pressure refuses to budge: exploring the complexity of resistant hypertension
title_fullStr When blood pressure refuses to budge: exploring the complexity of resistant hypertension
title_full_unstemmed When blood pressure refuses to budge: exploring the complexity of resistant hypertension
title_short When blood pressure refuses to budge: exploring the complexity of resistant hypertension
title_sort when blood pressure refuses to budge: exploring the complexity of resistant hypertension
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322223/
https://www.ncbi.nlm.nih.gov/pubmed/37416924
http://dx.doi.org/10.3389/fcvm.2023.1211199
work_keys_str_mv AT champaneriameetikeyur whenbloodpressurerefusestobudgeexploringthecomplexityofresistanthypertension
AT patelrushisanjaykumar whenbloodpressurerefusestobudgeexploringthecomplexityofresistanthypertension
AT orosziterryl whenbloodpressurerefusestobudgeexploringthecomplexityofresistanthypertension