Cargando…
When blood pressure refuses to budge: exploring the complexity of resistant hypertension
Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite t...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322223/ https://www.ncbi.nlm.nih.gov/pubmed/37416924 http://dx.doi.org/10.3389/fcvm.2023.1211199 |
_version_ | 1785068705382662144 |
---|---|
author | Champaneria, Meeti Keyur Patel, Rushi Sanjaykumar Oroszi, Terry L. |
author_facet | Champaneria, Meeti Keyur Patel, Rushi Sanjaykumar Oroszi, Terry L. |
author_sort | Champaneria, Meeti Keyur |
collection | PubMed |
description | Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite the availability of a wide range of pharmacological therapies, achieving optimal blood pressure control in patients with resistant hypertension remains a significant challenge. However, recent advances in the field have identified several promising treatment options, including spironolactone, mineralocorticoid receptor antagonists, and renal denervation. In addition, personalized management approaches based on genetic and other biomarkers may offer new opportunities to tailor therapy and improve outcomes. This review aims to provide an overview of the current state of knowledge regarding managing resistant hypertension, including the epidemiology, pathophysiology, and clinical implications of the condition, as well as the latest developments in therapeutic strategies and future prospects. |
format | Online Article Text |
id | pubmed-10322223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103222232023-07-06 When blood pressure refuses to budge: exploring the complexity of resistant hypertension Champaneria, Meeti Keyur Patel, Rushi Sanjaykumar Oroszi, Terry L. Front Cardiovasc Med Cardiovascular Medicine Resistant hypertension, defined as blood pressure that remains above goal despite using three or more antihypertensive medications, including a diuretic, affects a significant proportion of the hypertensive population and is associated with increased cardiovascular morbidity and mortality. Despite the availability of a wide range of pharmacological therapies, achieving optimal blood pressure control in patients with resistant hypertension remains a significant challenge. However, recent advances in the field have identified several promising treatment options, including spironolactone, mineralocorticoid receptor antagonists, and renal denervation. In addition, personalized management approaches based on genetic and other biomarkers may offer new opportunities to tailor therapy and improve outcomes. This review aims to provide an overview of the current state of knowledge regarding managing resistant hypertension, including the epidemiology, pathophysiology, and clinical implications of the condition, as well as the latest developments in therapeutic strategies and future prospects. Frontiers Media S.A. 2023-06-21 /pmc/articles/PMC10322223/ /pubmed/37416924 http://dx.doi.org/10.3389/fcvm.2023.1211199 Text en © 2023 Champaneria, Patel and Oroszi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Champaneria, Meeti Keyur Patel, Rushi Sanjaykumar Oroszi, Terry L. When blood pressure refuses to budge: exploring the complexity of resistant hypertension |
title | When blood pressure refuses to budge: exploring the complexity of resistant hypertension |
title_full | When blood pressure refuses to budge: exploring the complexity of resistant hypertension |
title_fullStr | When blood pressure refuses to budge: exploring the complexity of resistant hypertension |
title_full_unstemmed | When blood pressure refuses to budge: exploring the complexity of resistant hypertension |
title_short | When blood pressure refuses to budge: exploring the complexity of resistant hypertension |
title_sort | when blood pressure refuses to budge: exploring the complexity of resistant hypertension |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322223/ https://www.ncbi.nlm.nih.gov/pubmed/37416924 http://dx.doi.org/10.3389/fcvm.2023.1211199 |
work_keys_str_mv | AT champaneriameetikeyur whenbloodpressurerefusestobudgeexploringthecomplexityofresistanthypertension AT patelrushisanjaykumar whenbloodpressurerefusestobudgeexploringthecomplexityofresistanthypertension AT orosziterryl whenbloodpressurerefusestobudgeexploringthecomplexityofresistanthypertension |