TAp63, a methotrexate target in CD4(+) T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis

Methotrexate (MTX) is a standard, first-line therapy for rheumatoid arthritis (RA); however, its precise mechanisms of action other than antifolate activity are largely unknown. We performed DNA microarray analyses of CD4(+) T cells in patients with RA before and after MTX treatment and found that T...

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Detalles Bibliográficos
Autores principales: Suga, Kensuke, Suto, Akira, Tanaka, Shigeru, Sugawara, Yutaka, Kageyama, Takahiro, Ishikawa, Junichi, Sanayama, Yoshie, Ikeda, Kei, Furuta, Shunsuke, Kagami, Shin-Ichiro, Iwata, Arifumi, Hirose, Koichi, Suzuki, Kotaro, Ohara, Osamu, Nakajima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322677/
https://www.ncbi.nlm.nih.gov/pubmed/37212280
http://dx.doi.org/10.1172/jci.insight.164778

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