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Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells

To improve our limited understanding of the pathogenesis of thoracic aortic aneurysm (TAA) that leads to acute aortic dissection, single-cell RNA sequencing (scRNA-seq) was employed to profile disease-relevant transcriptomic changes of aortic cell populations in a well-characterized mouse model of t...

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Detalles Bibliográficos
Autores principales:	Sun, Yifei, Asano, Keiichi, Sedes, Lauriane, Cantalupo, Anna, Hansen, Jens, Iyengar, Ravi, Walsh, Martin J., Ramirez, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322683/ https://www.ncbi.nlm.nih.gov/pubmed/37022786 http://dx.doi.org/10.1172/jci.insight.168793

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