Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs. Mutations in the chloroquine (CQ) resistance transporter, pf...

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Detalles Bibliográficos
Autores principales: Amambua-Ngwa, Alfred, Button-Simons, Katrina A., Li, Xue, Kumar, Sudhir, Brenneman, Katelyn Vendrely, Ferrari, Marco, Checkley, Lisa A., Haile, Meseret T., Shoue, Douglas A., McDew-White, Marina, Tindall, Sarah M., Reyes, Ann, Delgado, Elizabeth, Dalhoff, Haley, Larbalestier, James K., Amato, Roberto, Pearson, Richard D., Taylor, Alexander B., Nosten, François H., D’Alessandro, Umberto, Kwiatkowski, Dominic, Cheeseman, Ian H., Kappe, Stefan H. I., Avery, Simon V., Conway, David J., Vaughan, Ashley M., Ferdig, Michael T., Anderson, Timothy J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322710/
https://www.ncbi.nlm.nih.gov/pubmed/37169919
http://dx.doi.org/10.1038/s41564-023-01377-z

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