Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo

The absence of orthogonal aminoacyl-transfer RNA (tRNA) synthetases that accept non-l-α-amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined hetero-oligomers and biomaterials. Here we report that pyrrolysyl-tRNA synthetase (PylRS) and certain PylRS variants accep...

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Detalles Bibliográficos
Autores principales: Fricke, Riley, Swenson, Cameron V., Roe, Leah Tang, Hamlish, Noah Xue, Shah, Bhavana, Zhang, Zhongqi, Ficaretta, Elise, Ad, Omer, Smaga, Sarah, Gee, Christine L., Chatterjee, Abhishek, Schepartz, Alanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322718/
https://www.ncbi.nlm.nih.gov/pubmed/37264106
http://dx.doi.org/10.1038/s41557-023-01224-y

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