Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis

The role of growth differentiation factor (GDF)-11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates heart failure under pressure overload condition via impairing the...

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Detalles Bibliográficos
Autores principales: Zhu, Jinyun, Zhang, Ning, Zhao, Yun, Liu, Qi, Wang, Yingchao, Chen, Mingyao, Ma, Qunchao, Dong, Aiqiang, Wang, Yaping, Yu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322730/
https://www.ncbi.nlm.nih.gov/pubmed/37426531
http://dx.doi.org/10.1016/j.jacbts.2022.11.004
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author Zhu, Jinyun
Zhang, Ning
Zhao, Yun
Liu, Qi
Wang, Yingchao
Chen, Mingyao
Ma, Qunchao
Dong, Aiqiang
Wang, Yaping
Yu, Hong
author_facet Zhu, Jinyun
Zhang, Ning
Zhao, Yun
Liu, Qi
Wang, Yingchao
Chen, Mingyao
Ma, Qunchao
Dong, Aiqiang
Wang, Yaping
Yu, Hong
author_sort Zhu, Jinyun
collection PubMed
description The role of growth differentiation factor (GDF)-11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates heart failure under pressure overload condition via impairing the responsive angiogenesis. GDF-11 induced VEGF expression in CMs by activating the Akt/mTOR pathway. The effect of endogenous GDF-11 on the heart belongs to local self-regulation of myocardial tissue, rather than a way of systemic regulation.
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spelling pubmed-103227302023-07-07 Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis Zhu, Jinyun Zhang, Ning Zhao, Yun Liu, Qi Wang, Yingchao Chen, Mingyao Ma, Qunchao Dong, Aiqiang Wang, Yaping Yu, Hong JACC Basic Transl Sci Original Research - Preclinical The role of growth differentiation factor (GDF)-11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates heart failure under pressure overload condition via impairing the responsive angiogenesis. GDF-11 induced VEGF expression in CMs by activating the Akt/mTOR pathway. The effect of endogenous GDF-11 on the heart belongs to local self-regulation of myocardial tissue, rather than a way of systemic regulation. Elsevier 2023-02-22 /pmc/articles/PMC10322730/ /pubmed/37426531 http://dx.doi.org/10.1016/j.jacbts.2022.11.004 Text en © 2023 Published by Elsevier on behalf of the American College of Cardiology Foundation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Preclinical
Zhu, Jinyun
Zhang, Ning
Zhao, Yun
Liu, Qi
Wang, Yingchao
Chen, Mingyao
Ma, Qunchao
Dong, Aiqiang
Wang, Yaping
Yu, Hong
Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
title Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
title_full Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
title_fullStr Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
title_full_unstemmed Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
title_short Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis
title_sort deficiency of gdf-11 accelerates tac-induced heart failure by impairing cardiac angiogenesis
topic Original Research - Preclinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322730/
https://www.ncbi.nlm.nih.gov/pubmed/37426531
http://dx.doi.org/10.1016/j.jacbts.2022.11.004
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