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Fir(e)ing the Rhythm: Inflammatory Cytokines and Cardiac Arrhythmias

Inflammatory activation is increasingly recognized as a nonconventional risk factor for arrhythmias, and experimental studies provided robust evidence that this association is mediated by direct arrhythmogenic effects of proinflammatory cytokines on cardiac cells. Additionally, inflammatory cytokine...

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Detalles Bibliográficos
Autores principales: Lazzerini, Pietro Enea, Abbate, Antonio, Boutjdir, Mohamed, Capecchi, Pier Leopoldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322731/
https://www.ncbi.nlm.nih.gov/pubmed/37426535
http://dx.doi.org/10.1016/j.jacbts.2022.12.004
Descripción
Sumario:Inflammatory activation is increasingly recognized as a nonconventional risk factor for arrhythmias, and experimental studies provided robust evidence that this association is mediated by direct arrhythmogenic effects of proinflammatory cytokines on cardiac cells. Additionally, inflammatory cytokines can favor arrhythmias indirectly through multiple systemic effects. Accumulating data confirm the clinical relevance of these mechanisms; the largest evidence being available for atrial fibrillation, acquired long-QT syndrome, and ventricular arrhythmias. However, clinical management of arrhythmias largely neglects inflammatory cytokines. This review integrates basic science and clinical research to present an updated overview of the topic and provides future directions for patient’s management.