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A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population

Aims: Aortic diseases (ADs), including aortic dissection, aortic aneurysm, and aortic rupture, are fatal, with extremely high mortality rates. A body shape index (ABSI), an anthropometric measure calculated as waist circumference adjusted by height and weight, improves the predictive capacity for mo...

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Autores principales: Otaki, Yoichiro, Watanabe, Tetsu, Konta, Tsuneo, Watanabe, Masafumi, Fujimoto, Shouichi, Sato, Yuji, Asahi, Koichi, Yamagata, Kunihiro, Tsuruya, Kazuhiko, Narita, Ichiei, Kasahara, Masato, Shibagaki, Yugo, Iseki, Kunitoshi, Moriyama, Toshiki, Kondo, Masahide, Watanabe, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322738/
https://www.ncbi.nlm.nih.gov/pubmed/36070887
http://dx.doi.org/10.5551/jat.63753
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author Otaki, Yoichiro
Watanabe, Tetsu
Konta, Tsuneo
Watanabe, Masafumi
Fujimoto, Shouichi
Sato, Yuji
Asahi, Koichi
Yamagata, Kunihiro
Tsuruya, Kazuhiko
Narita, Ichiei
Kasahara, Masato
Shibagaki, Yugo
Iseki, Kunitoshi
Moriyama, Toshiki
Kondo, Masahide
Watanabe, Tsuyoshi
author_facet Otaki, Yoichiro
Watanabe, Tetsu
Konta, Tsuneo
Watanabe, Masafumi
Fujimoto, Shouichi
Sato, Yuji
Asahi, Koichi
Yamagata, Kunihiro
Tsuruya, Kazuhiko
Narita, Ichiei
Kasahara, Masato
Shibagaki, Yugo
Iseki, Kunitoshi
Moriyama, Toshiki
Kondo, Masahide
Watanabe, Tsuyoshi
author_sort Otaki, Yoichiro
collection PubMed
description Aims: Aortic diseases (ADs), including aortic dissection, aortic aneurysm, and aortic rupture, are fatal, with extremely high mortality rates. A body shape index (ABSI), an anthropometric measure calculated as waist circumference adjusted by height and weight, improves the predictive capacity for mortality. However, whether ABSI is a risk factor for AD-related mortality in the general population remains unclear. Methods: We used a nationwide database of 630,842 individuals (aged 40–75 years) who participated in the annual “Specific Health Check and Guidance in Japan” between 2008 and 2010. Results: During the follow-up period of 3.8 years, 159 AD-related deaths occurred, including 105 aortic dissections and 54 aortic aneurysm ruptures. The subjects were divided into three groups based on ABSI tertiles. Kaplan–Meier analysis demonstrated that the 3(rd) tertile (with the highest ABSI) had the greatest risk among the three groups. Multivariate Cox proportional hazard regression analysis demonstrated that ABSI was significantly associated with AD-related death after adjusting for confounding risk factors. Neither waist circumference nor body mass index consistently predicted AD-related death in the multivariate model. The prediction capacity was significantly improved by the addition of ABSI to the confounding risk factors. Conclusions: We demonstrated for the first time that ABSI, a surrogate marker for abdominal visceral fat tissue, was associated with AD-related deaths in the general population, suggesting the importance of central adiposity in the development of AD.
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spelling pubmed-103227382023-07-07 A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population Otaki, Yoichiro Watanabe, Tetsu Konta, Tsuneo Watanabe, Masafumi Fujimoto, Shouichi Sato, Yuji Asahi, Koichi Yamagata, Kunihiro Tsuruya, Kazuhiko Narita, Ichiei Kasahara, Masato Shibagaki, Yugo Iseki, Kunitoshi Moriyama, Toshiki Kondo, Masahide Watanabe, Tsuyoshi J Atheroscler Thromb Original Article Aims: Aortic diseases (ADs), including aortic dissection, aortic aneurysm, and aortic rupture, are fatal, with extremely high mortality rates. A body shape index (ABSI), an anthropometric measure calculated as waist circumference adjusted by height and weight, improves the predictive capacity for mortality. However, whether ABSI is a risk factor for AD-related mortality in the general population remains unclear. Methods: We used a nationwide database of 630,842 individuals (aged 40–75 years) who participated in the annual “Specific Health Check and Guidance in Japan” between 2008 and 2010. Results: During the follow-up period of 3.8 years, 159 AD-related deaths occurred, including 105 aortic dissections and 54 aortic aneurysm ruptures. The subjects were divided into three groups based on ABSI tertiles. Kaplan–Meier analysis demonstrated that the 3(rd) tertile (with the highest ABSI) had the greatest risk among the three groups. Multivariate Cox proportional hazard regression analysis demonstrated that ABSI was significantly associated with AD-related death after adjusting for confounding risk factors. Neither waist circumference nor body mass index consistently predicted AD-related death in the multivariate model. The prediction capacity was significantly improved by the addition of ABSI to the confounding risk factors. Conclusions: We demonstrated for the first time that ABSI, a surrogate marker for abdominal visceral fat tissue, was associated with AD-related deaths in the general population, suggesting the importance of central adiposity in the development of AD. Japan Atherosclerosis Society 2023-07-01 2022-09-07 /pmc/articles/PMC10322738/ /pubmed/36070887 http://dx.doi.org/10.5551/jat.63753 Text en 2023 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Article
Otaki, Yoichiro
Watanabe, Tetsu
Konta, Tsuneo
Watanabe, Masafumi
Fujimoto, Shouichi
Sato, Yuji
Asahi, Koichi
Yamagata, Kunihiro
Tsuruya, Kazuhiko
Narita, Ichiei
Kasahara, Masato
Shibagaki, Yugo
Iseki, Kunitoshi
Moriyama, Toshiki
Kondo, Masahide
Watanabe, Tsuyoshi
A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population
title A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population
title_full A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population
title_fullStr A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population
title_full_unstemmed A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population
title_short A Body Shape Index and Aortic Disease-Related Mortality in Japanese General Population
title_sort body shape index and aortic disease-related mortality in japanese general population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322738/
https://www.ncbi.nlm.nih.gov/pubmed/36070887
http://dx.doi.org/10.5551/jat.63753
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