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Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin

Compared to rifampicin (600 mg/day), standard doses of rifabutin (300 mg/day) have a lower risk of drug–drug interactions due to induction of cytochrome P450 3A4 (CYP3A4) or P-glycoprotein (Pgp/ABCB1) mediated by the pregnane X receptor (PXR). However, clinical comparisons with equal rifamycin doses...

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Detalles Bibliográficos
Autores principales:	Nilles, Julie, Weiss, Johanna, Sauter, Max, Haefeli, Walter E., Ruez, Stephanie, Theile, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322781/ https://www.ncbi.nlm.nih.gov/pubmed/37285043 http://dx.doi.org/10.1007/s00204-023-03531-2

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