UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1)...

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Detalles Bibliográficos
Autores principales: Kostyrko, Kaja, Román, Marta, Lee, Alex G., Simpson, David R., Dinh, Phuong T., Leung, Stanley G., Marini, Kieren D., Kelly, Marcus R., Broyde, Joshua, Califano, Andrea, Jackson, Peter K., Sweet-Cordero, E. Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322837/
https://www.ncbi.nlm.nih.gov/pubmed/37407562
http://dx.doi.org/10.1038/s41467-023-39591-2

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