The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C, an autosomal recessive lysosomal disorder characterized by progressive neurodegeneration and early death. Here, we use s...

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Detalles Bibliográficos
Autores principales: Kunkel, Thaddeus J., Townsend, Alice, Sullivan, Kyle A., Merlet, Jean, Schuchman, Edward H., Jacobson, Daniel A., Lieberman, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322873/
https://www.ncbi.nlm.nih.gov/pubmed/37407594
http://dx.doi.org/10.1038/s41467-023-39733-6

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