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Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess
Pyogenic liver abscess (PLA) is a severe condition that significantly increases the risk of sepsis. However, there is a notable dearth of research regarding the prediction of sepsis in PLA patients. The objective of this study was to develop and validate a prognostic nomogram for predicting sepsis i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322897/ https://www.ncbi.nlm.nih.gov/pubmed/37407641 http://dx.doi.org/10.1038/s41598-023-37907-2 |
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author | Li, Ji Wang, Yin Luo, Jinhong Yin, Zhikun Huang, Weifeng Zhang, Jinyan |
author_facet | Li, Ji Wang, Yin Luo, Jinhong Yin, Zhikun Huang, Weifeng Zhang, Jinyan |
author_sort | Li, Ji |
collection | PubMed |
description | Pyogenic liver abscess (PLA) is a severe condition that significantly increases the risk of sepsis. However, there is a notable dearth of research regarding the prediction of sepsis in PLA patients. The objective of this study was to develop and validate a prognostic nomogram for predicting sepsis in PLA patients. A total of 206 PLA patients were enrolled in our study, out of which 60 individuals (29.1%) met the Sepsis-3 criteria. Independent risk factors for sepsis were identified through univariate and multivariate logistic regression analyses. Subsequently, a nomogram was developed based on age, positive blood culture, procalcitonin, alanine aminotransferase, blood urea nitrogen, and d-dimer. The nomogram demonstrated excellent calibration and discrimination, as evidenced by the area under the receiver operating characteristic curve (AUC) values of 0.946 (95% confidence interval [CI], 0.912–0.979) and 0.980 (95%CI 0.951–1.000) in the derivation and validation cohorts, respectively. Furthermore, decision-curve analysis confirmed the clinical utility of the nomogram. This study provides valuable insights for the prevention of sepsis in PLA patients and underscores the potential application of the prognostic nomogram in clinical practice. |
format | Online Article Text |
id | pubmed-10322897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103228972023-07-07 Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess Li, Ji Wang, Yin Luo, Jinhong Yin, Zhikun Huang, Weifeng Zhang, Jinyan Sci Rep Article Pyogenic liver abscess (PLA) is a severe condition that significantly increases the risk of sepsis. However, there is a notable dearth of research regarding the prediction of sepsis in PLA patients. The objective of this study was to develop and validate a prognostic nomogram for predicting sepsis in PLA patients. A total of 206 PLA patients were enrolled in our study, out of which 60 individuals (29.1%) met the Sepsis-3 criteria. Independent risk factors for sepsis were identified through univariate and multivariate logistic regression analyses. Subsequently, a nomogram was developed based on age, positive blood culture, procalcitonin, alanine aminotransferase, blood urea nitrogen, and d-dimer. The nomogram demonstrated excellent calibration and discrimination, as evidenced by the area under the receiver operating characteristic curve (AUC) values of 0.946 (95% confidence interval [CI], 0.912–0.979) and 0.980 (95%CI 0.951–1.000) in the derivation and validation cohorts, respectively. Furthermore, decision-curve analysis confirmed the clinical utility of the nomogram. This study provides valuable insights for the prevention of sepsis in PLA patients and underscores the potential application of the prognostic nomogram in clinical practice. Nature Publishing Group UK 2023-07-05 /pmc/articles/PMC10322897/ /pubmed/37407641 http://dx.doi.org/10.1038/s41598-023-37907-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Ji Wang, Yin Luo, Jinhong Yin, Zhikun Huang, Weifeng Zhang, Jinyan Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
title | Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
title_full | Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
title_fullStr | Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
title_full_unstemmed | Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
title_short | Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
title_sort | development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322897/ https://www.ncbi.nlm.nih.gov/pubmed/37407641 http://dx.doi.org/10.1038/s41598-023-37907-2 |
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