IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease

Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet therapeutic development has remained stagnant. Skeletal muscle health and function has been strongly linked to quality of life and medical outcomes in patients with PAD. Using a rodent model of PAD, this study demonst...

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Detalles Bibliográficos
Autores principales: Dong, Gengfu, Moparthy, Chatick, Thome, Trace, Kim, Kyoungrae, Yue, Feng, Ryan, Terence E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322901/
https://www.ncbi.nlm.nih.gov/pubmed/37426532
http://dx.doi.org/10.1016/j.jacbts.2022.12.006
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author Dong, Gengfu
Moparthy, Chatick
Thome, Trace
Kim, Kyoungrae
Yue, Feng
Ryan, Terence E.
author_facet Dong, Gengfu
Moparthy, Chatick
Thome, Trace
Kim, Kyoungrae
Yue, Feng
Ryan, Terence E.
author_sort Dong, Gengfu
collection PubMed
description Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet therapeutic development has remained stagnant. Skeletal muscle health and function has been strongly linked to quality of life and medical outcomes in patients with PAD. Using a rodent model of PAD, this study demonstrates that treatment of the ischemic limb with insulin-like growth factor (IGF)-1 significantly increases muscle size and strength without improving limb hemodynamics. Interestingly, the effect size of IGF1 therapy was larger in female mice than in male mice, highlighting the need to carefully examine sex-dependent effects in experimental PAD therapies.
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spelling pubmed-103229012023-07-07 IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease Dong, Gengfu Moparthy, Chatick Thome, Trace Kim, Kyoungrae Yue, Feng Ryan, Terence E. JACC Basic Transl Sci Original Research - Preclinical Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet therapeutic development has remained stagnant. Skeletal muscle health and function has been strongly linked to quality of life and medical outcomes in patients with PAD. Using a rodent model of PAD, this study demonstrates that treatment of the ischemic limb with insulin-like growth factor (IGF)-1 significantly increases muscle size and strength without improving limb hemodynamics. Interestingly, the effect size of IGF1 therapy was larger in female mice than in male mice, highlighting the need to carefully examine sex-dependent effects in experimental PAD therapies. Elsevier 2023-03-08 /pmc/articles/PMC10322901/ /pubmed/37426532 http://dx.doi.org/10.1016/j.jacbts.2022.12.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Preclinical
Dong, Gengfu
Moparthy, Chatick
Thome, Trace
Kim, Kyoungrae
Yue, Feng
Ryan, Terence E.
IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
title IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
title_full IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
title_fullStr IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
title_full_unstemmed IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
title_short IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
title_sort igf-1 therapy improves muscle size and function in experimental peripheral arterial disease
topic Original Research - Preclinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322901/
https://www.ncbi.nlm.nih.gov/pubmed/37426532
http://dx.doi.org/10.1016/j.jacbts.2022.12.006
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