Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity

Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG-repeat expansions in the huntingtin (HTT) gene. The resulting mutant HTT (mHTT) protein induces toxicity and cell death via multiple mechanisms and no effective therapy is available. Here, we employ a genome-wide screening in pl...

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Detalles Bibliográficos
Autores principales: Ferlazzo, Giorgia Maria, Gambetta, Anna Maria, Amato, Sonia, Cannizzaro, Noemi, Angiolillo, Silvia, Arboit, Mattia, Diamante, Linda, Carbognin, Elena, Romani, Patrizia, La Torre, Federico, Galimberti, Elena, Pflug, Florian, Luoni, Mirko, Giannelli, Serena, Pepe, Giuseppe, Capocci, Luca, Di Pardo, Alba, Vanzani, Paola, Zennaro, Lucio, Broccoli, Vania, Leeb, Martin, Moro, Enrico, Maglione, Vittorio, Martello, Graziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322923/
https://www.ncbi.nlm.nih.gov/pubmed/37407555
http://dx.doi.org/10.1038/s41467-023-39552-9

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