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An attempt to model the causal structure behind white matter aging and cognitive decline

In this diffusion tension imaging study, voxel wise structural equation modeling was used to unravel the relation between white matter, cognition, and age. Four neurocognitive ageing models describing the interplay between age, white matter integrity, and cognition were investigated but only two mod...

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Autores principales: Koten, Jan Willem, Koschutnig, Karl, Wood, Guilherme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322973/
https://www.ncbi.nlm.nih.gov/pubmed/37407647
http://dx.doi.org/10.1038/s41598-023-37925-0
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author Koten, Jan Willem
Koschutnig, Karl
Wood, Guilherme
author_facet Koten, Jan Willem
Koschutnig, Karl
Wood, Guilherme
author_sort Koten, Jan Willem
collection PubMed
description In this diffusion tension imaging study, voxel wise structural equation modeling was used to unravel the relation between white matter, cognition, and age. Four neurocognitive ageing models describing the interplay between age, white matter integrity, and cognition were investigated but only two models survived an Akaike information criterion-based model selection procedure. The independent factor model predicts that there is no relation between white matter integrity and cognition although both systems are affected by age. The cognitive mediation model predicts that the relation between age and white matter integrity is mediated through cognition. Roughly 60% of the observed voxels were in agreement with the independent factor model while 16% of the observed voxels were in agreement with the cognitive mediation model. Imaging results of the latter model suggest that the deterioration of fibers—that connect the two hemispheres with each other—is partly caused by an age-related decline in cognitive functioning.
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spelling pubmed-103229732023-07-07 An attempt to model the causal structure behind white matter aging and cognitive decline Koten, Jan Willem Koschutnig, Karl Wood, Guilherme Sci Rep Article In this diffusion tension imaging study, voxel wise structural equation modeling was used to unravel the relation between white matter, cognition, and age. Four neurocognitive ageing models describing the interplay between age, white matter integrity, and cognition were investigated but only two models survived an Akaike information criterion-based model selection procedure. The independent factor model predicts that there is no relation between white matter integrity and cognition although both systems are affected by age. The cognitive mediation model predicts that the relation between age and white matter integrity is mediated through cognition. Roughly 60% of the observed voxels were in agreement with the independent factor model while 16% of the observed voxels were in agreement with the cognitive mediation model. Imaging results of the latter model suggest that the deterioration of fibers—that connect the two hemispheres with each other—is partly caused by an age-related decline in cognitive functioning. Nature Publishing Group UK 2023-07-05 /pmc/articles/PMC10322973/ /pubmed/37407647 http://dx.doi.org/10.1038/s41598-023-37925-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Koten, Jan Willem
Koschutnig, Karl
Wood, Guilherme
An attempt to model the causal structure behind white matter aging and cognitive decline
title An attempt to model the causal structure behind white matter aging and cognitive decline
title_full An attempt to model the causal structure behind white matter aging and cognitive decline
title_fullStr An attempt to model the causal structure behind white matter aging and cognitive decline
title_full_unstemmed An attempt to model the causal structure behind white matter aging and cognitive decline
title_short An attempt to model the causal structure behind white matter aging and cognitive decline
title_sort attempt to model the causal structure behind white matter aging and cognitive decline
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322973/
https://www.ncbi.nlm.nih.gov/pubmed/37407647
http://dx.doi.org/10.1038/s41598-023-37925-0
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