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Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy

We examined the effect of reduced fluence (rf)-photodynamic therapy (PDT) of the macular area on the wide-field choroidal thickness in 20 eyes with central serous chorioretinopathy (CSC) and 20 age- and sex-matched control eyes. The choroidal thickness at the posterior pole was measured before and a...

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Autores principales: Nishigori, Naomi, Muraoka, Yuki, Ishikura, Masaharu, Kogo, Takahiro, Ueda-Arakawa, Naoko, Miyata, Manabu, Tamura, Hiroshi, Hata, Masayuki, Takahashi, Ayako, Miyake, Masahiro, Tsujikawa, Akitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322984/
https://www.ncbi.nlm.nih.gov/pubmed/37407690
http://dx.doi.org/10.1038/s41598-023-37802-w
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author Nishigori, Naomi
Muraoka, Yuki
Ishikura, Masaharu
Kogo, Takahiro
Ueda-Arakawa, Naoko
Miyata, Manabu
Tamura, Hiroshi
Hata, Masayuki
Takahashi, Ayako
Miyake, Masahiro
Tsujikawa, Akitaka
author_facet Nishigori, Naomi
Muraoka, Yuki
Ishikura, Masaharu
Kogo, Takahiro
Ueda-Arakawa, Naoko
Miyata, Manabu
Tamura, Hiroshi
Hata, Masayuki
Takahashi, Ayako
Miyake, Masahiro
Tsujikawa, Akitaka
author_sort Nishigori, Naomi
collection PubMed
description We examined the effect of reduced fluence (rf)-photodynamic therapy (PDT) of the macular area on the wide-field choroidal thickness in 20 eyes with central serous chorioretinopathy (CSC) and 20 age- and sex-matched control eyes. The choroidal thickness at the posterior pole was measured before and after rf-PDT, using a grid with inner and outer rings, each divided into superotemporal, inferotemporal, superonasal, and inferonasal quadrants, respectively, making up a total of nine subfields including the central 3 mm ring. Before treatment, all eyes showed wide-field choroidal thickening from the dilated vortex vein ampulla to the fovea, along the course of the vein. After rf-PDT of the macular area, the choroidal thickness significantly decreased, not only in the irradiated macular area but also outside the arcade vessels in all quadrants (p < 0.001 for all inner subfields; p = 0.035 and p = 0.024 for the outer superonasal and inferonasal subfields, respectively; p < 0.001 and p = 0.004 for the outer superotemporal and inferotemporal subfields, respectively). For control eyes, the choroidal thickness did not differ between the initial visit and follow-up 1.2 ± 0.7 months after the initial visit (p > 0.05 for all subfields). These findings provide new insights into the pathogenesis of CSC and explain the reasons for the effectiveness of rf-PDT for this condition.
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spelling pubmed-103229842023-07-07 Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy Nishigori, Naomi Muraoka, Yuki Ishikura, Masaharu Kogo, Takahiro Ueda-Arakawa, Naoko Miyata, Manabu Tamura, Hiroshi Hata, Masayuki Takahashi, Ayako Miyake, Masahiro Tsujikawa, Akitaka Sci Rep Article We examined the effect of reduced fluence (rf)-photodynamic therapy (PDT) of the macular area on the wide-field choroidal thickness in 20 eyes with central serous chorioretinopathy (CSC) and 20 age- and sex-matched control eyes. The choroidal thickness at the posterior pole was measured before and after rf-PDT, using a grid with inner and outer rings, each divided into superotemporal, inferotemporal, superonasal, and inferonasal quadrants, respectively, making up a total of nine subfields including the central 3 mm ring. Before treatment, all eyes showed wide-field choroidal thickening from the dilated vortex vein ampulla to the fovea, along the course of the vein. After rf-PDT of the macular area, the choroidal thickness significantly decreased, not only in the irradiated macular area but also outside the arcade vessels in all quadrants (p < 0.001 for all inner subfields; p = 0.035 and p = 0.024 for the outer superonasal and inferonasal subfields, respectively; p < 0.001 and p = 0.004 for the outer superotemporal and inferotemporal subfields, respectively). For control eyes, the choroidal thickness did not differ between the initial visit and follow-up 1.2 ± 0.7 months after the initial visit (p > 0.05 for all subfields). These findings provide new insights into the pathogenesis of CSC and explain the reasons for the effectiveness of rf-PDT for this condition. Nature Publishing Group UK 2023-07-05 /pmc/articles/PMC10322984/ /pubmed/37407690 http://dx.doi.org/10.1038/s41598-023-37802-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nishigori, Naomi
Muraoka, Yuki
Ishikura, Masaharu
Kogo, Takahiro
Ueda-Arakawa, Naoko
Miyata, Manabu
Tamura, Hiroshi
Hata, Masayuki
Takahashi, Ayako
Miyake, Masahiro
Tsujikawa, Akitaka
Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
title Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
title_full Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
title_fullStr Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
title_full_unstemmed Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
title_short Extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
title_sort extensive reduction in choroidal thickness after photodynamic therapy in eyes with central serous chorioretinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322984/
https://www.ncbi.nlm.nih.gov/pubmed/37407690
http://dx.doi.org/10.1038/s41598-023-37802-w
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