Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease

Here, we present a protocol for conducting magnetic resonance imaging proton density fat fraction (MRI-PDFF) to measure intrahepatic triglyceride (IHTG) content in adults with non-alcohol fatty liver disease (NAFLD). We describe steps for screening patients for NAFLD, MRI-PDFF scanning, and using MR...

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Detalles Bibliográficos
Autores principales: Ezpeleta, Mark, Gabel, Kelsey, Cienfuegos, Sofia, Lin, Shuhao, Pavlou, Vasiliki, Varady, Krista A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323010/
https://www.ncbi.nlm.nih.gov/pubmed/37071529
http://dx.doi.org/10.1016/j.xpro.2023.102230
Descripción
Sumario:Here, we present a protocol for conducting magnetic resonance imaging proton density fat fraction (MRI-PDFF) to measure intrahepatic triglyceride (IHTG) content in adults with non-alcohol fatty liver disease (NAFLD). We describe steps for screening patients for NAFLD, MRI-PDFF scanning, and using MRI-PDFF data to quantify IHTG. This protocol can be repeated sequentially and used in weight loss trials. However, it is limited to patients with NAFLD as it does not assess non-alcoholic steatohepatitis or hepatic fibrosis. For complete details on the use and execution of this protocol, please refer to Ezpeleta et al. (2023).(1)

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