Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease

Here, we present a protocol for conducting magnetic resonance imaging proton density fat fraction (MRI-PDFF) to measure intrahepatic triglyceride (IHTG) content in adults with non-alcohol fatty liver disease (NAFLD). We describe steps for screening patients for NAFLD, MRI-PDFF scanning, and using MR...

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Detalles Bibliográficos
Autores principales: Ezpeleta, Mark, Gabel, Kelsey, Cienfuegos, Sofia, Lin, Shuhao, Pavlou, Vasiliki, Varady, Krista A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323010/
https://www.ncbi.nlm.nih.gov/pubmed/37071529
http://dx.doi.org/10.1016/j.xpro.2023.102230
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author Ezpeleta, Mark
Gabel, Kelsey
Cienfuegos, Sofia
Lin, Shuhao
Pavlou, Vasiliki
Varady, Krista A.
author_facet Ezpeleta, Mark
Gabel, Kelsey
Cienfuegos, Sofia
Lin, Shuhao
Pavlou, Vasiliki
Varady, Krista A.
author_sort Ezpeleta, Mark
collection PubMed
description Here, we present a protocol for conducting magnetic resonance imaging proton density fat fraction (MRI-PDFF) to measure intrahepatic triglyceride (IHTG) content in adults with non-alcohol fatty liver disease (NAFLD). We describe steps for screening patients for NAFLD, MRI-PDFF scanning, and using MRI-PDFF data to quantify IHTG. This protocol can be repeated sequentially and used in weight loss trials. However, it is limited to patients with NAFLD as it does not assess non-alcoholic steatohepatitis or hepatic fibrosis. For complete details on the use and execution of this protocol, please refer to Ezpeleta et al. (2023).(1)
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spelling pubmed-103230102023-07-07 Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease Ezpeleta, Mark Gabel, Kelsey Cienfuegos, Sofia Lin, Shuhao Pavlou, Vasiliki Varady, Krista A. STAR Protoc Protocol Here, we present a protocol for conducting magnetic resonance imaging proton density fat fraction (MRI-PDFF) to measure intrahepatic triglyceride (IHTG) content in adults with non-alcohol fatty liver disease (NAFLD). We describe steps for screening patients for NAFLD, MRI-PDFF scanning, and using MRI-PDFF data to quantify IHTG. This protocol can be repeated sequentially and used in weight loss trials. However, it is limited to patients with NAFLD as it does not assess non-alcoholic steatohepatitis or hepatic fibrosis. For complete details on the use and execution of this protocol, please refer to Ezpeleta et al. (2023).(1) Elsevier 2023-04-17 /pmc/articles/PMC10323010/ /pubmed/37071529 http://dx.doi.org/10.1016/j.xpro.2023.102230 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Ezpeleta, Mark
Gabel, Kelsey
Cienfuegos, Sofia
Lin, Shuhao
Pavlou, Vasiliki
Varady, Krista A.
Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
title Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
title_full Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
title_fullStr Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
title_full_unstemmed Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
title_short Protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
title_sort protocol for measuring intrahepatic triglyceride content in adults with non-alcohol fatty liver disease
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323010/
https://www.ncbi.nlm.nih.gov/pubmed/37071529
http://dx.doi.org/10.1016/j.xpro.2023.102230
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