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Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the microbiome becomes perturbed, causing dysbiosis. Increa...

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Detalles Bibliográficos
Autor principal: Sin, Don D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323206/
https://www.ncbi.nlm.nih.gov/pubmed/37038880
http://dx.doi.org/10.4046/trd.2023.0015
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author Sin, Don D.
author_facet Sin, Don D.
author_sort Sin, Don D.
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description Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the microbiome becomes perturbed, causing dysbiosis. Increased representation of members in the Proteobacteria phylum and certain members in the Firmicutes phylum has been associated with increased risk of exacerbations and mortality. Therapies such as inhaled corticosteroids and azithromycin may modulate the airway microbiome or its metabolites in patients with COPD. This paper provides an up-to-date overview of the airway microbiome and its importance in the pathophysiology of COPD and as potential therapeutic target in the future.
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spelling pubmed-103232062023-07-07 Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know Sin, Don D. Tuberc Respir Dis (Seoul) Review Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the microbiome becomes perturbed, causing dysbiosis. Increased representation of members in the Proteobacteria phylum and certain members in the Firmicutes phylum has been associated with increased risk of exacerbations and mortality. Therapies such as inhaled corticosteroids and azithromycin may modulate the airway microbiome or its metabolites in patients with COPD. This paper provides an up-to-date overview of the airway microbiome and its importance in the pathophysiology of COPD and as potential therapeutic target in the future. The Korean Academy of Tuberculosis and Respiratory Diseases 2023-07 2023-04-11 /pmc/articles/PMC10323206/ /pubmed/37038880 http://dx.doi.org/10.4046/trd.2023.0015 Text en Copyright © 2023 The Korean Academy of Tuberculosis and Respiratory Diseases https://creativecommons.org/licenses/by-nc/4.0/It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ).
spellingShingle Review
Sin, Don D.
Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know
title Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know
title_full Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know
title_fullStr Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know
title_full_unstemmed Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know
title_short Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know
title_sort chronic obstructive pulmonary disease and the airway microbiome: what respirologists need to know
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323206/
https://www.ncbi.nlm.nih.gov/pubmed/37038880
http://dx.doi.org/10.4046/trd.2023.0015
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