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Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report

Patient: Female, 63-year-old Final Diagnosis: Neuroendocrine tumor Symptoms: None Clinical Procedure: — Specialty: Gastroenterology and Hepatology OBJECTIVE: Rare disease BACKGROUND: Various neoplasms, including neuroendocrine neoplasms (NENs), can arise from the presacral space. Most presacral lesi...

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Autores principales: Watanabe, Takafumi, Yoon, Seitetsu, Yamakawa, Kohei, Hyodo, Toshiki, Izaki, Kenta, Okada, Hirofumi, Shirakawa, Yutaka, Ebisutani, Chikara, Sakamoto, Yoshio, Hirohata, Shigeya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323222/
https://www.ncbi.nlm.nih.gov/pubmed/37391901
http://dx.doi.org/10.12659/AJCR.939614
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author Watanabe, Takafumi
Yoon, Seitetsu
Yamakawa, Kohei
Hyodo, Toshiki
Izaki, Kenta
Okada, Hirofumi
Shirakawa, Yutaka
Ebisutani, Chikara
Sakamoto, Yoshio
Hirohata, Shigeya
author_facet Watanabe, Takafumi
Yoon, Seitetsu
Yamakawa, Kohei
Hyodo, Toshiki
Izaki, Kenta
Okada, Hirofumi
Shirakawa, Yutaka
Ebisutani, Chikara
Sakamoto, Yoshio
Hirohata, Shigeya
author_sort Watanabe, Takafumi
collection PubMed
description Patient: Female, 63-year-old Final Diagnosis: Neuroendocrine tumor Symptoms: None Clinical Procedure: — Specialty: Gastroenterology and Hepatology OBJECTIVE: Rare disease BACKGROUND: Various neoplasms, including neuroendocrine neoplasms (NENs), can arise from the presacral space. Most presacral lesions are detected due to symptoms arising from tumor growth. However, diagnosing small, asymptomatic presacral tumors is challenging because of their unique location. CASE REPORT: A 63-year-old woman with chronic hepatitis C underwent follow-up after achieving a sustained virological response. Abdominal ultrasonography revealed multiple new hyperechoic masses in the liver. Physical and laboratory examinations, including tumor marker analysis, yielded unremarkable results. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated metastatic liver tumors but failed to identify the primary site of these lesions. The hepatic mass was biopsied, leading to a diagnosis of grade 2 neuroendocrine tumor. (111)In-pentetreotide somatostatin receptor scintigraphy revealed significant radiotracer accumulation in multiple hepatic masses, several bones, and a small presacral space lesion. Pathological examination of the presacral lesion confirmed a grade 2 neuroendocrine tumor, similar to the hepatic mass. Review of a CT scan performed 4 years earlier indicated a small cyst-like lesion in the presacral space suspected of being a developmental cyst; however, the presence of cystic components was not confirmed pathologically. The patient was diagnosed with a primary presacral neuroendocrine tumor, which might have originated from a developmental cyst, with multiple liver metastases. Chemotherapy with everolimus was initiated, and the clinical course has been uneventful. CONCLUSIONS: We report a rare neuroendocrine tumor arising from the presacral space with multiple liver metastases. The presacral space should be examined when a NEN with an unknown primary site is found.
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spelling pubmed-103232222023-07-07 Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report Watanabe, Takafumi Yoon, Seitetsu Yamakawa, Kohei Hyodo, Toshiki Izaki, Kenta Okada, Hirofumi Shirakawa, Yutaka Ebisutani, Chikara Sakamoto, Yoshio Hirohata, Shigeya Am J Case Rep Articles Patient: Female, 63-year-old Final Diagnosis: Neuroendocrine tumor Symptoms: None Clinical Procedure: — Specialty: Gastroenterology and Hepatology OBJECTIVE: Rare disease BACKGROUND: Various neoplasms, including neuroendocrine neoplasms (NENs), can arise from the presacral space. Most presacral lesions are detected due to symptoms arising from tumor growth. However, diagnosing small, asymptomatic presacral tumors is challenging because of their unique location. CASE REPORT: A 63-year-old woman with chronic hepatitis C underwent follow-up after achieving a sustained virological response. Abdominal ultrasonography revealed multiple new hyperechoic masses in the liver. Physical and laboratory examinations, including tumor marker analysis, yielded unremarkable results. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated metastatic liver tumors but failed to identify the primary site of these lesions. The hepatic mass was biopsied, leading to a diagnosis of grade 2 neuroendocrine tumor. (111)In-pentetreotide somatostatin receptor scintigraphy revealed significant radiotracer accumulation in multiple hepatic masses, several bones, and a small presacral space lesion. Pathological examination of the presacral lesion confirmed a grade 2 neuroendocrine tumor, similar to the hepatic mass. Review of a CT scan performed 4 years earlier indicated a small cyst-like lesion in the presacral space suspected of being a developmental cyst; however, the presence of cystic components was not confirmed pathologically. The patient was diagnosed with a primary presacral neuroendocrine tumor, which might have originated from a developmental cyst, with multiple liver metastases. Chemotherapy with everolimus was initiated, and the clinical course has been uneventful. CONCLUSIONS: We report a rare neuroendocrine tumor arising from the presacral space with multiple liver metastases. The presacral space should be examined when a NEN with an unknown primary site is found. International Scientific Literature, Inc. 2023-07-01 /pmc/articles/PMC10323222/ /pubmed/37391901 http://dx.doi.org/10.12659/AJCR.939614 Text en © Am J Case Rep, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Watanabe, Takafumi
Yoon, Seitetsu
Yamakawa, Kohei
Hyodo, Toshiki
Izaki, Kenta
Okada, Hirofumi
Shirakawa, Yutaka
Ebisutani, Chikara
Sakamoto, Yoshio
Hirohata, Shigeya
Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report
title Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report
title_full Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report
title_fullStr Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report
title_full_unstemmed Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report
title_short Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report
title_sort primary presacral neuroendocrine tumor presenting as multiple liver metastasis: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323222/
https://www.ncbi.nlm.nih.gov/pubmed/37391901
http://dx.doi.org/10.12659/AJCR.939614
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