Cargando…
Advanced T and Natural Killer Cell Therapy for Glioblastoma
Although immunotherapy has been broadly successful in the treatment of hematologic malignancies and a subset of solid tumors, its clinical outcomes for glioblastoma are still inadequate. The results could be due to neuroanatomical structures such as the blood-brain-barrier, antigenic heterogeneity,...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurosurgical Society
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323271/ https://www.ncbi.nlm.nih.gov/pubmed/36588388 http://dx.doi.org/10.3340/jkns.2022.0267 |
_version_ | 1785068932187553792 |
---|---|
author | Yoon, Wan-Soo Chung, Dong-Sup |
author_facet | Yoon, Wan-Soo Chung, Dong-Sup |
author_sort | Yoon, Wan-Soo |
collection | PubMed |
description | Although immunotherapy has been broadly successful in the treatment of hematologic malignancies and a subset of solid tumors, its clinical outcomes for glioblastoma are still inadequate. The results could be due to neuroanatomical structures such as the blood-brain-barrier, antigenic heterogeneity, and the highly immunosuppressive microenvironment of glioblastomas. The antitumor efficacy of endogenously activated effector cells induced by peptide or dendritic cell vaccines in particular has been insufficient to control tumors. Effector cells, such as T cells and natural killer (NK) cells can be expanded rapidly ex vivo and transferred to patients. The identification of neoantigens derived from tumor-specific mutations is expanding the list of tumor-specific antigens for glioblastoma. Moreover, recent advances in gene-editing technologies enable the effector cells to not only have multiple biological functionalities, such as cytokine production, multiple antigen recognition, and increased cell trafficking, but also relieve the immunosuppressive nature of the glioblastoma microenvironment by blocking immune inhibitory molecules, which together improve their cytotoxicity, persistence, and safety. Allogeneic chimeric antigen receptor (CAR) T cells edited to reduce graft-versus-host disease and allorejection, or induced pluripotent stem cell-derived NK cells expressing CARs that use NK-specific signaling domain can be a good candidate for off-the-shelf products of glioblastoma immunotherapy. We here discuss current progress and future directions for T cell and NK cell therapy in glioblastoma. |
format | Online Article Text |
id | pubmed-10323271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-103232712023-07-07 Advanced T and Natural Killer Cell Therapy for Glioblastoma Yoon, Wan-Soo Chung, Dong-Sup J Korean Neurosurg Soc Review Article Although immunotherapy has been broadly successful in the treatment of hematologic malignancies and a subset of solid tumors, its clinical outcomes for glioblastoma are still inadequate. The results could be due to neuroanatomical structures such as the blood-brain-barrier, antigenic heterogeneity, and the highly immunosuppressive microenvironment of glioblastomas. The antitumor efficacy of endogenously activated effector cells induced by peptide or dendritic cell vaccines in particular has been insufficient to control tumors. Effector cells, such as T cells and natural killer (NK) cells can be expanded rapidly ex vivo and transferred to patients. The identification of neoantigens derived from tumor-specific mutations is expanding the list of tumor-specific antigens for glioblastoma. Moreover, recent advances in gene-editing technologies enable the effector cells to not only have multiple biological functionalities, such as cytokine production, multiple antigen recognition, and increased cell trafficking, but also relieve the immunosuppressive nature of the glioblastoma microenvironment by blocking immune inhibitory molecules, which together improve their cytotoxicity, persistence, and safety. Allogeneic chimeric antigen receptor (CAR) T cells edited to reduce graft-versus-host disease and allorejection, or induced pluripotent stem cell-derived NK cells expressing CARs that use NK-specific signaling domain can be a good candidate for off-the-shelf products of glioblastoma immunotherapy. We here discuss current progress and future directions for T cell and NK cell therapy in glioblastoma. Korean Neurosurgical Society 2023-07 2023-01-02 /pmc/articles/PMC10323271/ /pubmed/36588388 http://dx.doi.org/10.3340/jkns.2022.0267 Text en Copyright © 2023 The Korean Neurosurgical Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yoon, Wan-Soo Chung, Dong-Sup Advanced T and Natural Killer Cell Therapy for Glioblastoma |
title | Advanced T and Natural Killer Cell Therapy for Glioblastoma |
title_full | Advanced T and Natural Killer Cell Therapy for Glioblastoma |
title_fullStr | Advanced T and Natural Killer Cell Therapy for Glioblastoma |
title_full_unstemmed | Advanced T and Natural Killer Cell Therapy for Glioblastoma |
title_short | Advanced T and Natural Killer Cell Therapy for Glioblastoma |
title_sort | advanced t and natural killer cell therapy for glioblastoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323271/ https://www.ncbi.nlm.nih.gov/pubmed/36588388 http://dx.doi.org/10.3340/jkns.2022.0267 |
work_keys_str_mv | AT yoonwansoo advancedtandnaturalkillercelltherapyforglioblastoma AT chungdongsup advancedtandnaturalkillercelltherapyforglioblastoma |