Cargando…

Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania spp

Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5 million new cases each year. Despite the new approaches and advances to fight the disease, there are no effective therapies. Methods: Hence, this study aims to screen for natural products' structural analog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barazorda-Ccahuana, Haruna Luz, Goyzueta-Mamani, Luis Daniel, Candia Puma, Mayron Antonio, Simões de Freitas, Camila, de Sousa Vieria Tavares, Grasiele, Pagliara Lage, Daniela, Ferraz Coelho, Eduardo Antonio, Chávez-Fumagalli, Miguel Angel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323282/ https://www.ncbi.nlm.nih.gov/pubmed/37424744 http://dx.doi.org/10.12688/f1000research.129943.3

Ejemplares similares

Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach
por: Goyzueta-Mamani, Luis Daniel, et al.
Publicado: (2021)

PeruNPDB: the Peruvian Natural Products Database for in silico drug screening
por: Barazorda-Ccahuana, Haruna L., et al.
Publicado: (2023)

A Systematic Review and Meta-Analysis Comparing the Diagnostic Accuracy Tests of COVID-19
por: Vilca-Alosilla, Juan Jeferson, et al.
Publicado: (2023)

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease
por: Goyzueta-Mamani, Luis Daniel, et al.
Publicado: (2022)

A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species
por: Chávez-Fumagalli, Miguel Angel, et al.
Publicado: (2018)

Accuracy of Diagnostic Tests for the Detection of Chagas Disease: A Systematic Review and Meta-Analysis
por: Candia-Puma, Mayron Antonio, et al.
Publicado: (2022)

Effect of pH on the Supramolecular Structure of Helicobacter pylori Urease by Molecular Dynamics Simulations
por: Barazorda-Ccahuana, Haruna L., et al.
Publicado: (2020)

Unveiling the Effect of Low pH on the SARS-CoV-2 Main Protease by Molecular Dynamics Simulations
por: Barazorda-Ccahuana, Haruna Luz, et al.
Publicado: (2021)

Heat-Stable Hazelnut Profilin: Molecular Dynamics Simulations and Immunoinformatics Analysis
por: Barazorda-Ccahuana, Haruna L., et al.
Publicado: (2020)

Cinnamides Target Leishmania amazonensis Arginase Selectively
por: da Silva, Edson Roberto, et al.
Publicado: (2020)

Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis
por: Acuña, Stephanie Maia, et al.
Publicado: (2017)

Vibrational Analysis of Manganese(II) Oxalates Hydrates: An In Silico Statistical Approach
por: Barazorda-Ccahuana, Haruna L., et al.
Publicado: (2020)

Synthesis of 1,2,3-Triazole-Containing Methoxylated Cinnamides and Their Antileishmanial Activity against the Leishmania braziliensis Species
por: dos Santos, Fabíola Suelen, et al.
Publicado: (2023)

Antigenicity, Immunogenicity and Protective Efficacy of Three Proteins Expressed in the Promastigote and Amastigote Stages of Leishmania infantum against Visceral Leishmaniasis
por: Martins, Vivian Tamietti, et al.
Publicado: (2015)

Correction: Antigenicity, Immunogenicity and Protective Efficacy of Three Proteins Expressed in the Promastigote and Amastigote Stages of Leishmania infantum against Visceral Leishmaniasis
por: Martins, Vivian Tamietti, et al.
Publicado: (2015)

Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity
por: da Silva, Maria Fernanda Laranjeira, et al.
Publicado: (2012)

Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes
por: Boitz, Jan M., et al.
Publicado: (2016)

Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites
por: Badirzadeh, Alireza, et al.
Publicado: (2017)

Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise
por: Carter, Nicola S., et al.
Publicado: (2021)

Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances
por: Garcia, Andreza R., et al.
Publicado: (2019)

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents
por: Garcia, Andreza R., et al.
Publicado: (2021)

L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis
por: Aoki, Juliana Ide, et al.
Publicado: (2017)

Mimotope-Based Vaccines of Leishmania infantum Antigens and Their Protective Efficacy against Visceral Leishmaniasis
por: Costa, Lourena Emanuele, et al.
Publicado: (2014)

Toxicity and Anti-promastigote Activity of Benzoxazinoid Analogs Against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) infantum
por: de Sousa, Gilberto, et al.
Publicado: (2020)

Murine Susceptibility to Leishmania amazonensis Infection Is Influenced by Arginase-1 and Macrophages at the Lesion Site
por: Tomiotto-Pellissier, Fernanda, et al.
Publicado: (2021)

Benzimidazole Derivatives as New and Selective Inhibitors of Arginase from Leishmania mexicana with Biological Activity against Promastigotes and Amastigotes
por: Betancourt-Conde, Irene, et al.
Publicado: (2021)

Parasitological and immunological evaluation of a quinoline derivative salt incorporated into a polymeric micelle formulation against Leishmania infantum infection
por: Ribeiro Antinarelli, Luciana M., et al.
Publicado: (2022)

Immunotherapy Using Immunogenic Mimotopes Selected by Phage Display plus Amphotericin B Inducing a Therapeutic Response in Mice Infected with Leishmania amazonensis
por: Soyer, Tauane G., et al.
Publicado: (2023)

Identification of Proteins in Promastigote and Amastigote-like Leishmania Using an Immunoproteomic Approach
por: Coelho, Vinicio T. S., et al.
Publicado: (2012)

The Inhibition of Arginase by N (ω)-Hydroxy-l-Arginine Controls the Growth of Leishmania Inside Macrophages
por: Iniesta, Virginia, et al.
Publicado: (2001)

RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginase-dependent gene expression regulation
por: Aoki, Juliana Ide, et al.
Publicado: (2017)

Corrigendum: Murine Susceptibility to Leishmania amazonensis Infection Is Influenced by Arginase-1 and Macrophages at the Lesion Site
por: Tomiotto-Pellissier, Fernanda, et al.
Publicado: (2022)

Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions
por: dos Reis, Matheus Balduíno Goncalves, et al.
Publicado: (2013)

Identification of Differentially Expressed Proteins from Leishmania amazonensis Associated with the Loss of Virulence of the Parasites
por: Magalhães, Rubens D. M., et al.
Publicado: (2014)

Selection strategy of phage-displayed immunogens based on an in vitro evaluation of the Th1 response of PBMCs and their potential use as a vaccine against Leishmania infantum infection
por: Ramos, Fernanda Fonseca, et al.
Publicado: (2017)

Deciphering the Role Played by Autophagy in Leishmania Infection
por: Veras, Patricia Sampaio Tavares, et al.
Publicado: (2019)

Dual transcriptome analysis reveals differential gene expression modulation influenced by Leishmania arginase and host genetic background
por: Aoki, Juliana Ide, et al.
Publicado: (2020)

A Recombinant Chimeric Protein-Based Vaccine Containing T-Cell Epitopes from Amastigote Proteins and Combined with Distinct Adjuvants, Induces Immunogenicity and Protection against Leishmania infantum Infection
por: Lage, Daniela P., et al.
Publicado: (2022)

Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity
por: Lage, Paula Sousa, et al.
Publicado: (2013)

Structural and Energetic Affinity of Annocatacin B with ND1 Subunit of the Human Mitochondrial Respiratory Complex I as a Potential Inhibitor: An In Silico Comparison Study with the Known Inhibitor Rotenone
por: Febres-Molina, Camilo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t4o32q6ocf8qt3gj5lt246gb1r