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Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity

Brodmann area 8 (BA8) is traditionally defined as the prefrontal region of the human cerebrum just anterior to the premotor cortices and enveloping most of the superior frontal gyrus. Early studies have suggested the frontal eye fields are situated at its most caudal aspect, causing many to consider...

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Autores principales: Dadario, Nicholas B., Tanglay, Onur, Sughrue, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323427/
https://www.ncbi.nlm.nih.gov/pubmed/37426900
http://dx.doi.org/10.3389/fnana.2023.1127143
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author Dadario, Nicholas B.
Tanglay, Onur
Sughrue, Michael E.
author_facet Dadario, Nicholas B.
Tanglay, Onur
Sughrue, Michael E.
author_sort Dadario, Nicholas B.
collection PubMed
description Brodmann area 8 (BA8) is traditionally defined as the prefrontal region of the human cerebrum just anterior to the premotor cortices and enveloping most of the superior frontal gyrus. Early studies have suggested the frontal eye fields are situated at its most caudal aspect, causing many to consider BA8 as primarily an ocular center which controls contralateral gaze and attention. However, years of refinement in cytoarchitectural studies have challenged this traditional anatomical definition, providing a refined definition of its boundaries with neighboring cortical areas and the presence of meaningful subdivisions. Furthermore, functional imaging studies have suggested its involvement in a diverse number of higher-order functions, such as motor, cognition, and language. Thus, our traditional working definition of BA8 has likely been insufficient to truly understand the complex structural and functional significance of this area. Recently, large-scale multi-modal neuroimaging approaches have allowed for improved mapping of the neural connectivity of the human brain. Insight into the structural and functional connectivity of the brain connectome, comprised of large-scale brain networks, has allowed for greater understanding of complex neurological functioning and pathophysiological diseases states. Simultaneously, the structural and functional connectivity of BA8 has recently been highlighted in various neuroimaging studies and detailed anatomic dissections. However, while Brodmann’s nomenclature is still widely used today, such as for clinical discussions and the communication of research findings, the importance of the underlying connectivity of BA8 requires further review.
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spelling pubmed-103234272023-07-07 Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity Dadario, Nicholas B. Tanglay, Onur Sughrue, Michael E. Front Neuroanat Neuroanatomy Brodmann area 8 (BA8) is traditionally defined as the prefrontal region of the human cerebrum just anterior to the premotor cortices and enveloping most of the superior frontal gyrus. Early studies have suggested the frontal eye fields are situated at its most caudal aspect, causing many to consider BA8 as primarily an ocular center which controls contralateral gaze and attention. However, years of refinement in cytoarchitectural studies have challenged this traditional anatomical definition, providing a refined definition of its boundaries with neighboring cortical areas and the presence of meaningful subdivisions. Furthermore, functional imaging studies have suggested its involvement in a diverse number of higher-order functions, such as motor, cognition, and language. Thus, our traditional working definition of BA8 has likely been insufficient to truly understand the complex structural and functional significance of this area. Recently, large-scale multi-modal neuroimaging approaches have allowed for improved mapping of the neural connectivity of the human brain. Insight into the structural and functional connectivity of the brain connectome, comprised of large-scale brain networks, has allowed for greater understanding of complex neurological functioning and pathophysiological diseases states. Simultaneously, the structural and functional connectivity of BA8 has recently been highlighted in various neuroimaging studies and detailed anatomic dissections. However, while Brodmann’s nomenclature is still widely used today, such as for clinical discussions and the communication of research findings, the importance of the underlying connectivity of BA8 requires further review. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10323427/ /pubmed/37426900 http://dx.doi.org/10.3389/fnana.2023.1127143 Text en Copyright © 2023 Dadario, Tanglay and Sughrue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroanatomy
Dadario, Nicholas B.
Tanglay, Onur
Sughrue, Michael E.
Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity
title Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity
title_full Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity
title_fullStr Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity
title_full_unstemmed Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity
title_short Deconvoluting human Brodmann area 8 based on its unique structural and functional connectivity
title_sort deconvoluting human brodmann area 8 based on its unique structural and functional connectivity
topic Neuroanatomy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323427/
https://www.ncbi.nlm.nih.gov/pubmed/37426900
http://dx.doi.org/10.3389/fnana.2023.1127143
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