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Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review
BACKGROUND AND OBJECTIVE: The poor oncologic outcomes associated with esophageal cancer (EC) are primarily due to its presentation at an advanced stage and patient comorbidities. While multimodal therapy improves overall outcomes, there is a lack of uniform practice in terms of perioperative managem...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323549/ https://www.ncbi.nlm.nih.gov/pubmed/37426147 http://dx.doi.org/10.21037/jtd-23-27 |
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author | Mukherji, Reetu Alqahtani, Ali Yin, Chao Caso, Raul Noel, Marcus S. Khaitan, Puja Gaur |
author_facet | Mukherji, Reetu Alqahtani, Ali Yin, Chao Caso, Raul Noel, Marcus S. Khaitan, Puja Gaur |
author_sort | Mukherji, Reetu |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: The poor oncologic outcomes associated with esophageal cancer (EC) are primarily due to its presentation at an advanced stage and patient comorbidities. While multimodal therapy improves overall outcomes, there is a lack of uniform practice in terms of perioperative management, partly because this is a rapidly evolving field in a heterogeneous patient population. With numerous recent studies incorporating precision medicine with radiographic, pathologic, and genomic biomarkers and with emerging trials using targeted therapies, it is necessary for providers who care for these patients to be familiar with the current and evolving treatment standards to optimize patient outcomes. The objective of this paper is to perform an updated review of the main historical and recently emerging studies that impact the perioperative management of patients with locally advanced, upfront-resectable EC. METHODS: We mined and reviewed PubMed and American Society of Clinical Oncology databases for pivotal works shaping the current perioperative treatment landscape in locally advanced EC. KEY CONTENT AND FINDINGS: EC are a vastly heterogeneous disease, and treatment options vary based on tumor anatomic location, histology, and patient comorbidities. Perioperative chemotherapy (CTX), chemoradiation (CRT), and, recently, immunotherapy have improved survival in patients with locally advanced disease. However, optimizing sequencing, de-escalating therapy, and incorporating novel targeted therapies in the perioperative setting are promising strategies that are under ongoing investigation to improve patient outcomes further. CONCLUSIONS: There is an ongoing need to identify predictive biomarkers and novel treatment strategies to personalize perioperative approaches and optimize outcomes of patients with EC. |
format | Online Article Text |
id | pubmed-10323549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-103235492023-07-07 Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review Mukherji, Reetu Alqahtani, Ali Yin, Chao Caso, Raul Noel, Marcus S. Khaitan, Puja Gaur J Thorac Dis Review Article BACKGROUND AND OBJECTIVE: The poor oncologic outcomes associated with esophageal cancer (EC) are primarily due to its presentation at an advanced stage and patient comorbidities. While multimodal therapy improves overall outcomes, there is a lack of uniform practice in terms of perioperative management, partly because this is a rapidly evolving field in a heterogeneous patient population. With numerous recent studies incorporating precision medicine with radiographic, pathologic, and genomic biomarkers and with emerging trials using targeted therapies, it is necessary for providers who care for these patients to be familiar with the current and evolving treatment standards to optimize patient outcomes. The objective of this paper is to perform an updated review of the main historical and recently emerging studies that impact the perioperative management of patients with locally advanced, upfront-resectable EC. METHODS: We mined and reviewed PubMed and American Society of Clinical Oncology databases for pivotal works shaping the current perioperative treatment landscape in locally advanced EC. KEY CONTENT AND FINDINGS: EC are a vastly heterogeneous disease, and treatment options vary based on tumor anatomic location, histology, and patient comorbidities. Perioperative chemotherapy (CTX), chemoradiation (CRT), and, recently, immunotherapy have improved survival in patients with locally advanced disease. However, optimizing sequencing, de-escalating therapy, and incorporating novel targeted therapies in the perioperative setting are promising strategies that are under ongoing investigation to improve patient outcomes further. CONCLUSIONS: There is an ongoing need to identify predictive biomarkers and novel treatment strategies to personalize perioperative approaches and optimize outcomes of patients with EC. AME Publishing Company 2023-06-13 2023-06-30 /pmc/articles/PMC10323549/ /pubmed/37426147 http://dx.doi.org/10.21037/jtd-23-27 Text en 2023 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article Mukherji, Reetu Alqahtani, Ali Yin, Chao Caso, Raul Noel, Marcus S. Khaitan, Puja Gaur Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
title | Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
title_full | Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
title_fullStr | Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
title_full_unstemmed | Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
title_short | Perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
title_sort | perioperative therapy landscape for locally advanced, resectable esophageal cancer: an updated literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323549/ https://www.ncbi.nlm.nih.gov/pubmed/37426147 http://dx.doi.org/10.21037/jtd-23-27 |
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