A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)

Lipid Nanoparticles In article number 2301929, Dan Peer and colleagues developed novel ionizable lipids for improved delivery of mRNA payloads. Rational lipid design together with in vivo screening identified novel lipid‐based nanoparticles (LNPs) with enhanced cell trophism. This study suggests tha...

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Autores principales: Naidu, Gonna Somu, Yong, Seok‐Beom, Ramishetti, Srinivas, Rampado, Riccardo, Sharma, Preeti, Ezra, Assaf, Goldsmith, Meir, Hazan‐Halevy, Inbal, Chatterjee, Sushmita, Aitha, Anjaiah, Peer, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323603/
http://dx.doi.org/10.1002/advs.202370118
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author Naidu, Gonna Somu
Yong, Seok‐Beom
Ramishetti, Srinivas
Rampado, Riccardo
Sharma, Preeti
Ezra, Assaf
Goldsmith, Meir
Hazan‐Halevy, Inbal
Chatterjee, Sushmita
Aitha, Anjaiah
Peer, Dan
author_facet Naidu, Gonna Somu
Yong, Seok‐Beom
Ramishetti, Srinivas
Rampado, Riccardo
Sharma, Preeti
Ezra, Assaf
Goldsmith, Meir
Hazan‐Halevy, Inbal
Chatterjee, Sushmita
Aitha, Anjaiah
Peer, Dan
author_sort Naidu, Gonna Somu
collection PubMed
description Lipid Nanoparticles In article number 2301929, Dan Peer and colleagues developed novel ionizable lipids for improved delivery of mRNA payloads. Rational lipid design together with in vivo screening identified novel lipid‐based nanoparticles (LNPs) with enhanced cell trophism. This study suggests that a structural combination of lipid tail and linker can drive novel cell trophism of LNPs in vivo. [Image: see text]
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spelling pubmed-103236032023-07-07 A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023) Naidu, Gonna Somu Yong, Seok‐Beom Ramishetti, Srinivas Rampado, Riccardo Sharma, Preeti Ezra, Assaf Goldsmith, Meir Hazan‐Halevy, Inbal Chatterjee, Sushmita Aitha, Anjaiah Peer, Dan Adv Sci (Weinh) Cover Picture Lipid Nanoparticles In article number 2301929, Dan Peer and colleagues developed novel ionizable lipids for improved delivery of mRNA payloads. Rational lipid design together with in vivo screening identified novel lipid‐based nanoparticles (LNPs) with enhanced cell trophism. This study suggests that a structural combination of lipid tail and linker can drive novel cell trophism of LNPs in vivo. [Image: see text] John Wiley and Sons Inc. 2023-07-06 /pmc/articles/PMC10323603/ http://dx.doi.org/10.1002/advs.202370118 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Naidu, Gonna Somu
Yong, Seok‐Beom
Ramishetti, Srinivas
Rampado, Riccardo
Sharma, Preeti
Ezra, Assaf
Goldsmith, Meir
Hazan‐Halevy, Inbal
Chatterjee, Sushmita
Aitha, Anjaiah
Peer, Dan
A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)
title A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)
title_full A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)
title_fullStr A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)
title_full_unstemmed A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)
title_short A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery (Adv. Sci. 19/2023)
title_sort combinatorial library of lipid nanoparticles for cell type‐specific mrna delivery (adv. sci. 19/2023)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323603/
http://dx.doi.org/10.1002/advs.202370118
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