DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)

T‐Cell Acute Lym‐phoblastic Leukemia In article number 2205854, Jingjing Ye, Min Ji, Chunyan Ji, and co‐workers observed aberrant adipogenesis in the bone marrow of chemotherapy‐treated T‐cell acute lymphoblastic leukemia (T‐ALL) patients, and the differentiated‐adipocytes attract and support residu...

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Autores principales: Jia, Ruinan, Sun, Tao, Zhao, Xin, Li, Guosheng, Xia, Yuan, Zhou, Ying, Li, Wěi, Li, Wei, Ma, Daoxin, Ye, Jingjing, Ji, Min, Ji, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323612/
http://dx.doi.org/10.1002/advs.202370125
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author Jia, Ruinan
Sun, Tao
Zhao, Xin
Li, Guosheng
Xia, Yuan
Zhou, Ying
Li, Wěi
Li, Wei
Ma, Daoxin
Ye, Jingjing
Ji, Min
Ji, Chunyan
author_facet Jia, Ruinan
Sun, Tao
Zhao, Xin
Li, Guosheng
Xia, Yuan
Zhou, Ying
Li, Wěi
Li, Wei
Ma, Daoxin
Ye, Jingjing
Ji, Min
Ji, Chunyan
author_sort Jia, Ruinan
collection PubMed
description T‐Cell Acute Lym‐phoblastic Leukemia In article number 2205854, Jingjing Ye, Min Ji, Chunyan Ji, and co‐workers observed aberrant adipogenesis in the bone marrow of chemotherapy‐treated T‐cell acute lymphoblastic leukemia (T‐ALL) patients, and the differentiated‐adipocytes attract and support residual T‐ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect of dexamethason by reducing adipogenesis and provides a feasible strategy to solve the dilemma of recurrence. [Image: see text]
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spelling pubmed-103236122023-07-07 DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023) Jia, Ruinan Sun, Tao Zhao, Xin Li, Guosheng Xia, Yuan Zhou, Ying Li, Wěi Li, Wei Ma, Daoxin Ye, Jingjing Ji, Min Ji, Chunyan Adv Sci (Weinh) Back Cover T‐Cell Acute Lym‐phoblastic Leukemia In article number 2205854, Jingjing Ye, Min Ji, Chunyan Ji, and co‐workers observed aberrant adipogenesis in the bone marrow of chemotherapy‐treated T‐cell acute lymphoblastic leukemia (T‐ALL) patients, and the differentiated‐adipocytes attract and support residual T‐ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect of dexamethason by reducing adipogenesis and provides a feasible strategy to solve the dilemma of recurrence. [Image: see text] John Wiley and Sons Inc. 2023-07-06 /pmc/articles/PMC10323612/ http://dx.doi.org/10.1002/advs.202370125 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Back Cover
Jia, Ruinan
Sun, Tao
Zhao, Xin
Li, Guosheng
Xia, Yuan
Zhou, Ying
Li, Wěi
Li, Wei
Ma, Daoxin
Ye, Jingjing
Ji, Min
Ji, Chunyan
DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)
title DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)
title_full DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)
title_fullStr DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)
title_full_unstemmed DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)
title_short DEX‐Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T‐Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy (Adv. Sci. 19/2023)
title_sort dex‐induced srebf1 promotes bmscs differentiation into adipocytes to attract and protect residual t‐cell acute lymphoblastic leukemia cells after chemotherapy (adv. sci. 19/2023)
topic Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323612/
http://dx.doi.org/10.1002/advs.202370125
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