KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

KMT2C and KMT2D are the most frequently mutated epigenetic genes in human cancers. While KMT2C is identified as a tumor suppressor in acute myeloid leukemia (AML), the role of KMT2D remains unclear in this disease, though its loss promotes B cell lymphoma and various solid cancers. Here, it is repor...

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Detalles Bibliográficos
Autores principales: Xu, Jing, Zhong, Ailing, Zhang, Shan, Chen, Mei, Zhang, Lanxin, Hang, Xiaohang, Zheng, Jianan, Wu, Baohong, Deng, Xintong, Pan, Xiangyu, Wang, Zhongwang, Qi, Lu, Shi, Kaidou, Li, Shujun, Wang, Yiyun, Wang, Manli, Chen, Xuelan, Zhang, Qi, Liu, Pengpeng, Gale, Robert Peter, Chen, Chong, Liu, Yu, Niu, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323629/
https://www.ncbi.nlm.nih.gov/pubmed/37142882
http://dx.doi.org/10.1002/advs.202206098

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