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Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives
With extended life expectancy, the quality of life of elders is a priority. Loss of mobility, increased morbidity and risks of falls have dramatic individual and societal impacts. Here we consider the age-related modifications of gait, from a biomechanical and neurophysiological perspective. Among t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323685/ https://www.ncbi.nlm.nih.gov/pubmed/37427405 http://dx.doi.org/10.3389/fphys.2023.1194889 |
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author | Nùñez-Lisboa, M. Valero-Breton, M. Dewolf, A. H. |
author_facet | Nùñez-Lisboa, M. Valero-Breton, M. Dewolf, A. H. |
author_sort | Nùñez-Lisboa, M. |
collection | PubMed |
description | With extended life expectancy, the quality of life of elders is a priority. Loss of mobility, increased morbidity and risks of falls have dramatic individual and societal impacts. Here we consider the age-related modifications of gait, from a biomechanical and neurophysiological perspective. Among the many factors of frailty involved (e.g., metabolic, hormonal, immunological), loss of muscle strength and neurodegenerative changes inducing slower muscle contraction may play a key role. We highlight that the impact of the multifactorial age-related changes in the neuromuscular systems results in common features of gait in the immature gait of infants and older adults. Besides, we also consider the reversibility of age-related neuromuscular deterioration by, on the one hand, exercise training, and the other hand, novel techniques such as direct spinal stimulation (tsDCS). |
format | Online Article Text |
id | pubmed-10323685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103236852023-07-07 Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives Nùñez-Lisboa, M. Valero-Breton, M. Dewolf, A. H. Front Physiol Physiology With extended life expectancy, the quality of life of elders is a priority. Loss of mobility, increased morbidity and risks of falls have dramatic individual and societal impacts. Here we consider the age-related modifications of gait, from a biomechanical and neurophysiological perspective. Among the many factors of frailty involved (e.g., metabolic, hormonal, immunological), loss of muscle strength and neurodegenerative changes inducing slower muscle contraction may play a key role. We highlight that the impact of the multifactorial age-related changes in the neuromuscular systems results in common features of gait in the immature gait of infants and older adults. Besides, we also consider the reversibility of age-related neuromuscular deterioration by, on the one hand, exercise training, and the other hand, novel techniques such as direct spinal stimulation (tsDCS). Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10323685/ /pubmed/37427405 http://dx.doi.org/10.3389/fphys.2023.1194889 Text en Copyright © 2023 Nùñez-Lisboa, Valero-Breton and Dewolf. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Nùñez-Lisboa, M. Valero-Breton, M. Dewolf, A. H. Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
title | Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
title_full | Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
title_fullStr | Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
title_full_unstemmed | Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
title_short | Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
title_sort | unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323685/ https://www.ncbi.nlm.nih.gov/pubmed/37427405 http://dx.doi.org/10.3389/fphys.2023.1194889 |
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