Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus

Studying vertical human immunodeficiency virus (HIV) transmission enables the impact of passively transferred antibodies on HIV transmission and pathogenesis to be examined. Using phage display of HIV envelope peptides and peptide enzyme-linked immunosorbent assay (ELISA), we found that, in infants...

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Autores principales: Yaffe, Zak A, Sung, Kevin, Bosire, Rose, Farquhar, Carey, Ngacha, Dorothy Mbori, Lohman-Payne, Barbara, Nduati, Ruth, John-Stewart, Grace, Matsen, Frederick A, Overbaugh, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323728/
https://www.ncbi.nlm.nih.gov/pubmed/37426948
http://dx.doi.org/10.1093/ofid/ofad316
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author Yaffe, Zak A
Sung, Kevin
Bosire, Rose
Farquhar, Carey
Ngacha, Dorothy Mbori
Lohman-Payne, Barbara
Nduati, Ruth
John-Stewart, Grace
Matsen, Frederick A
Overbaugh, Julie
author_facet Yaffe, Zak A
Sung, Kevin
Bosire, Rose
Farquhar, Carey
Ngacha, Dorothy Mbori
Lohman-Payne, Barbara
Nduati, Ruth
John-Stewart, Grace
Matsen, Frederick A
Overbaugh, Julie
author_sort Yaffe, Zak A
collection PubMed
description Studying vertical human immunodeficiency virus (HIV) transmission enables the impact of passively transferred antibodies on HIV transmission and pathogenesis to be examined. Using phage display of HIV envelope peptides and peptide enzyme-linked immunosorbent assay (ELISA), we found that, in infants who acquired HIV, passive antibody responses to constant region 5 (C5) were associated with improved survival in 2 cohorts. In a combined analysis, C5 peptide ELISA activity was correlated directly with survival and estimated infection time and inversely with set point viral load. These results suggest that preexisting C5-specific antibodies may be correlated with the survival of infants living with HIV, motivating additional research into their protective potential.
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spelling pubmed-103237282023-07-07 Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus Yaffe, Zak A Sung, Kevin Bosire, Rose Farquhar, Carey Ngacha, Dorothy Mbori Lohman-Payne, Barbara Nduati, Ruth John-Stewart, Grace Matsen, Frederick A Overbaugh, Julie Open Forum Infect Dis Brief Report Studying vertical human immunodeficiency virus (HIV) transmission enables the impact of passively transferred antibodies on HIV transmission and pathogenesis to be examined. Using phage display of HIV envelope peptides and peptide enzyme-linked immunosorbent assay (ELISA), we found that, in infants who acquired HIV, passive antibody responses to constant region 5 (C5) were associated with improved survival in 2 cohorts. In a combined analysis, C5 peptide ELISA activity was correlated directly with survival and estimated infection time and inversely with set point viral load. These results suggest that preexisting C5-specific antibodies may be correlated with the survival of infants living with HIV, motivating additional research into their protective potential. Oxford University Press 2023-06-14 /pmc/articles/PMC10323728/ /pubmed/37426948 http://dx.doi.org/10.1093/ofid/ofad316 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Yaffe, Zak A
Sung, Kevin
Bosire, Rose
Farquhar, Carey
Ngacha, Dorothy Mbori
Lohman-Payne, Barbara
Nduati, Ruth
John-Stewart, Grace
Matsen, Frederick A
Overbaugh, Julie
Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus
title Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus
title_full Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus
title_fullStr Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus
title_full_unstemmed Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus
title_short Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus
title_sort passively acquired constant region 5–specific antibodies associated with improved survival in infants who acquire human immunodeficiency virus
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323728/
https://www.ncbi.nlm.nih.gov/pubmed/37426948
http://dx.doi.org/10.1093/ofid/ofad316
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