MND1 enables homologous recombination in somatic cells primarily outside the context of replication

Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co‐factor MND1 facilitates the repair of DSBs in somatic cells. We show that MND1 localizes to DSBs, where it stimulates DNA repa...

Descripción completa

Detalles Bibliográficos
Autores principales: Koob, Lisa, Friskes, Anoek, van Bergen, Louise, Feringa, Femke M., van den Broek, Bram, Koeleman, Emma S., van Beek, Ellis, Schubert, Michael, Blomen, Vincent A., Brummelkamp, Thijn R., Krenning, Lenno, Medema, René H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323883/
https://www.ncbi.nlm.nih.gov/pubmed/37195379
http://dx.doi.org/10.1002/1878-0261.13448

Ejemplares similares

Ejemplares similares