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MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population
BACKGROUND AND AIM: The MBOAT7 rs641738 (C>T) variant has demonstrated an association with non-alcoholic fatty liver disease (NAFLD) in both adult and pediatric patients, while few studies have been conducted in elderly populations. Hence, a case–control study was undertaken to assess their corre...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324031/ https://www.ncbi.nlm.nih.gov/pubmed/37424875 http://dx.doi.org/10.3389/fendo.2023.1199429 |
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author | Xu, Xiaoyi Xu, Hangfei Liu, Xiaohui Zhang, Shuang Cao, Zhenhuan Qiu, Lixia Du, Xiaofei Liu, Yali Wang, Gang Zhang, Li Zhang, Yang Zhang, Jing |
author_facet | Xu, Xiaoyi Xu, Hangfei Liu, Xiaohui Zhang, Shuang Cao, Zhenhuan Qiu, Lixia Du, Xiaofei Liu, Yali Wang, Gang Zhang, Li Zhang, Yang Zhang, Jing |
author_sort | Xu, Xiaoyi |
collection | PubMed |
description | BACKGROUND AND AIM: The MBOAT7 rs641738 (C>T) variant has demonstrated an association with non-alcoholic fatty liver disease (NAFLD) in both adult and pediatric patients, while few studies have been conducted in elderly populations. Hence, a case–control study was undertaken to assess their correlation in elderly residents in a Beijing community. MATERIALS AND METHODS: A total of 1,287 participants were included. Medical history, abdominal ultrasound, and laboratory tests were recorded. Liver fat content and fibrosis stage were detected by Fibroscan. Genotyping of genomic DNA was performed using the 96.96 genotyping integrated fluidics circuit. RESULTS: Of the recruited subjects, 638 subjects (56.60%) had NAFLD, and 398 subjects (35.28%) had atherosclerotic cardiovascular disease (ASCVD). T allele carriage was associated with higher ALT (p=0.005) and significant fibrosis in male NAFLD patients (p=0.005) compared to CC genotype. TT genotype was associated with reduced risk of metabolic syndrome (OR=0.589, 95%CI: 0.114–0.683, p=0.005) and type 2 diabetes (OR=0.804, 95%CI: 0.277–0.296, p=0.048) in NAFLD population when compared to the CC genotype. In addition, TT genotype was also associated with reduced risk of ASCVD (OR=0.570, 95%CI:0.340–0.953, p=0.032) and less obesity (OR=0.545, 95%CI: 0.346–0.856, p=0.008) in the whole population. CONCLUSION: MBOAT7 rs641738 (C>T) variant was associated with fibrosis in male NAFLD patients. The variant also reduced risk of metabolic traits and type 2 diabetes in NAFLD and ASCVD risk in Chinese elders. |
format | Online Article Text |
id | pubmed-10324031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103240312023-07-07 MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population Xu, Xiaoyi Xu, Hangfei Liu, Xiaohui Zhang, Shuang Cao, Zhenhuan Qiu, Lixia Du, Xiaofei Liu, Yali Wang, Gang Zhang, Li Zhang, Yang Zhang, Jing Front Endocrinol (Lausanne) Endocrinology BACKGROUND AND AIM: The MBOAT7 rs641738 (C>T) variant has demonstrated an association with non-alcoholic fatty liver disease (NAFLD) in both adult and pediatric patients, while few studies have been conducted in elderly populations. Hence, a case–control study was undertaken to assess their correlation in elderly residents in a Beijing community. MATERIALS AND METHODS: A total of 1,287 participants were included. Medical history, abdominal ultrasound, and laboratory tests were recorded. Liver fat content and fibrosis stage were detected by Fibroscan. Genotyping of genomic DNA was performed using the 96.96 genotyping integrated fluidics circuit. RESULTS: Of the recruited subjects, 638 subjects (56.60%) had NAFLD, and 398 subjects (35.28%) had atherosclerotic cardiovascular disease (ASCVD). T allele carriage was associated with higher ALT (p=0.005) and significant fibrosis in male NAFLD patients (p=0.005) compared to CC genotype. TT genotype was associated with reduced risk of metabolic syndrome (OR=0.589, 95%CI: 0.114–0.683, p=0.005) and type 2 diabetes (OR=0.804, 95%CI: 0.277–0.296, p=0.048) in NAFLD population when compared to the CC genotype. In addition, TT genotype was also associated with reduced risk of ASCVD (OR=0.570, 95%CI:0.340–0.953, p=0.032) and less obesity (OR=0.545, 95%CI: 0.346–0.856, p=0.008) in the whole population. CONCLUSION: MBOAT7 rs641738 (C>T) variant was associated with fibrosis in male NAFLD patients. The variant also reduced risk of metabolic traits and type 2 diabetes in NAFLD and ASCVD risk in Chinese elders. Frontiers Media S.A. 2023-06-22 /pmc/articles/PMC10324031/ /pubmed/37424875 http://dx.doi.org/10.3389/fendo.2023.1199429 Text en Copyright © 2023 Xu, Xu, Liu, Zhang, Cao, Qiu, Du, Liu, Wang, Zhang, Zhang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Xu, Xiaoyi Xu, Hangfei Liu, Xiaohui Zhang, Shuang Cao, Zhenhuan Qiu, Lixia Du, Xiaofei Liu, Yali Wang, Gang Zhang, Li Zhang, Yang Zhang, Jing MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population |
title | MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population |
title_full | MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population |
title_fullStr | MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population |
title_full_unstemmed | MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population |
title_short | MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population |
title_sort | mboat7 rs641738 (c>t) is associated with nafld progression in men and decreased ascvd risk in elder chinese population |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324031/ https://www.ncbi.nlm.nih.gov/pubmed/37424875 http://dx.doi.org/10.3389/fendo.2023.1199429 |
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