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Quantification of Biologically Active DNA Alkylation in Temozolomide-Exposed Glioblastoma Cell Lines by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry: Method Development and Recommendations for Validation

[Image: see text] Quantitative monitoring of biologically active methylations of guanines in samples exposed to temozolomide (TMZ) would be useful in glioblastoma research for preclinical TMZ experiments, for clinical pharmacology questions regarding appropriate exposure, and ultimately for precisio...

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Detalles Bibliográficos
Autores principales:	Fresnais, Margaux, Jung, Ina, Klein, Uli B., Theile, Dirk, Liang, Siwen, Haefeli, Walter E., Burhenne, Jürgen, Longuespée, Rémi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324051/ https://www.ncbi.nlm.nih.gov/pubmed/37426236 http://dx.doi.org/10.1021/acsomega.3c01818

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