X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

BACKGROUND AND AIM: Sex differences in atherosclerosis have been described with female plaques being mostly perceived as stable and fibrous. Sex-specific mechanisms such as mosaic loss of the Y chromosome in men have been linked to cardiovascular health. In women, X-linked mechanisms such as X chrom...

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Detalles Bibliográficos
Autores principales: Buono, Michele F., Benavente, Ernest Diez, Daniels, Mark, Mol, Barend M., Mekke, Joost M., de Borst, Gert J., de Kleijn, Dominique P. V., van der Laan, Sander W., Pasterkamp, Gerard, Onland-Moret, Charlotte, Mokry, Michal, den Ruijter, Hester M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324263/
https://www.ncbi.nlm.nih.gov/pubmed/37408072
http://dx.doi.org/10.1186/s13293-023-00527-6

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