Dysregulated Rbfox2 produces aberrant splicing of Ca(V)1.2 calcium channel in diabetes-induced cardiac hypertrophy

BACKGROUND: L-type Ca(2+) channel Ca(V)1.2 is essential for cardiomyocyte excitation, contraction and gene transcription in the heart, and abnormal functions of cardiac Ca(V)1.2 channels are presented in diabetic cardiomyopathy. However, the underlying mechanisms are largely unclear. The functions o...

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Detalles Bibliográficos
Autores principales: Li, Pengpeng, Qin, Dongxia, Chen, Tiange, Hou, Wei, Song, Xinyu, Yin, Shumin, Song, Miaomiao, Fernando, W.C. Hewith A., Chen, Xiaojie, Sun, Yu, Wang, Juejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324275/
https://www.ncbi.nlm.nih.gov/pubmed/37415128
http://dx.doi.org/10.1186/s12933-023-01894-5

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