USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

BACKGROUND: Intervertebral disc degeneration (IDD) naturally occurs during the aging process. Its occurrence is closely related to chronic inflammation; however, the causal relationship between them is controversial. This study aimed to investigate if inflammation would promote IDD incidence and exp...

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Detalles Bibliográficos
Autores principales: Li, Xingguo, Zhang, Jun, Wang, Bing, Chen, Chao, Zhang, Enyu, Lv, Zhengpin, He, Qicong, Hu, Yaoquan, Wang, Xuenan, Zhang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324278/
https://www.ncbi.nlm.nih.gov/pubmed/37415159
http://dx.doi.org/10.1186/s13062-023-00395-5

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