Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis

[Image: see text] A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs.

Detalles Bibliográficos
Autores principales: Xue, Lijun, Ma, Hangke, Liu, Weijie, Duchemin, Nicolas, Zeng, Fanming, Zhang, Jie, Zhang, Huanqing, Yang, Kexin, Hu, Yun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324384/
https://www.ncbi.nlm.nih.gov/pubmed/37426273
http://dx.doi.org/10.1021/acsomega.3c03160
Descripción
Sumario:[Image: see text] A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs.

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