Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis

[Image: see text] A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs.

Detalles Bibliográficos
Autores principales: Xue, Lijun, Ma, Hangke, Liu, Weijie, Duchemin, Nicolas, Zeng, Fanming, Zhang, Jie, Zhang, Huanqing, Yang, Kexin, Hu, Yun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324384/
https://www.ncbi.nlm.nih.gov/pubmed/37426273
http://dx.doi.org/10.1021/acsomega.3c03160
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author Xue, Lijun
Ma, Hangke
Liu, Weijie
Duchemin, Nicolas
Zeng, Fanming
Zhang, Jie
Zhang, Huanqing
Yang, Kexin
Hu, Yun Jin
author_facet Xue, Lijun
Ma, Hangke
Liu, Weijie
Duchemin, Nicolas
Zeng, Fanming
Zhang, Jie
Zhang, Huanqing
Yang, Kexin
Hu, Yun Jin
author_sort Xue, Lijun
collection PubMed
description [Image: see text] A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs.
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spelling pubmed-103243842023-07-07 Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis Xue, Lijun Ma, Hangke Liu, Weijie Duchemin, Nicolas Zeng, Fanming Zhang, Jie Zhang, Huanqing Yang, Kexin Hu, Yun Jin ACS Omega [Image: see text] A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs. American Chemical Society 2023-06-19 /pmc/articles/PMC10324384/ /pubmed/37426273 http://dx.doi.org/10.1021/acsomega.3c03160 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Xue, Lijun
Ma, Hangke
Liu, Weijie
Duchemin, Nicolas
Zeng, Fanming
Zhang, Jie
Zhang, Huanqing
Yang, Kexin
Hu, Yun Jin
Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis
title Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis
title_full Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis
title_fullStr Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis
title_full_unstemmed Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis
title_short Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis
title_sort constructive on-dna thiol aerial oxidization for dna-encoded library synthesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324384/
https://www.ncbi.nlm.nih.gov/pubmed/37426273
http://dx.doi.org/10.1021/acsomega.3c03160
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