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Clinical relevance of stem cells in lung cancer

Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categori...

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Autores principales: Romeo, Horacio Eduardo, Barreiro Arcos, María Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324501/
https://www.ncbi.nlm.nih.gov/pubmed/37424954
http://dx.doi.org/10.4252/wjsc.v15.i6.576
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author Romeo, Horacio Eduardo
Barreiro Arcos, María Laura
author_facet Romeo, Horacio Eduardo
Barreiro Arcos, María Laura
author_sort Romeo, Horacio Eduardo
collection PubMed
description Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categorized into three distinct cell subtypes: Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC is the most common lung cancer, accounting for 85% of all lung cancers. Treatment for lung cancer is linked to the cell type and stage of the disease, involving chemotherapy, radiation therapy, and surgery. Despite improvements in therapeutic treatments, lung cancer patients show high rates of recurrence, metastasis, and resistance to chemotherapy. Lung stem cells (SCs) are undifferentiated cells capable of self-renewal and proliferation, are resistant to chemotherapy and radiotherapy and, due to their properties, could be involved in the development and progression of lung cancer. The presence of SCs in the lung tissue could be the reason why lung cancer is difficult to treat. The identification of lung cancer stem cells biomarkers is of interest for precision medicine using new therapeutic agents directed against these cell populations. In this review, we present the current knowledge on lung SCs and discuss their functional role in the initiation and progression of lung cancer, as well as their role in tumor resistance to chemotherapy.
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spelling pubmed-103245012023-07-07 Clinical relevance of stem cells in lung cancer Romeo, Horacio Eduardo Barreiro Arcos, María Laura World J Stem Cells Minireviews Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categorized into three distinct cell subtypes: Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC is the most common lung cancer, accounting for 85% of all lung cancers. Treatment for lung cancer is linked to the cell type and stage of the disease, involving chemotherapy, radiation therapy, and surgery. Despite improvements in therapeutic treatments, lung cancer patients show high rates of recurrence, metastasis, and resistance to chemotherapy. Lung stem cells (SCs) are undifferentiated cells capable of self-renewal and proliferation, are resistant to chemotherapy and radiotherapy and, due to their properties, could be involved in the development and progression of lung cancer. The presence of SCs in the lung tissue could be the reason why lung cancer is difficult to treat. The identification of lung cancer stem cells biomarkers is of interest for precision medicine using new therapeutic agents directed against these cell populations. In this review, we present the current knowledge on lung SCs and discuss their functional role in the initiation and progression of lung cancer, as well as their role in tumor resistance to chemotherapy. Baishideng Publishing Group Inc 2023-06-26 2023-06-26 /pmc/articles/PMC10324501/ /pubmed/37424954 http://dx.doi.org/10.4252/wjsc.v15.i6.576 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Romeo, Horacio Eduardo
Barreiro Arcos, María Laura
Clinical relevance of stem cells in lung cancer
title Clinical relevance of stem cells in lung cancer
title_full Clinical relevance of stem cells in lung cancer
title_fullStr Clinical relevance of stem cells in lung cancer
title_full_unstemmed Clinical relevance of stem cells in lung cancer
title_short Clinical relevance of stem cells in lung cancer
title_sort clinical relevance of stem cells in lung cancer
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324501/
https://www.ncbi.nlm.nih.gov/pubmed/37424954
http://dx.doi.org/10.4252/wjsc.v15.i6.576
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