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Advances of nanotechnology applied to cancer stem cells

Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, proliferation, and differentiation potential. The elimination of C...

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Autores principales: Yue, Miao, Guo, Ting, Nie, Deng-Yun, Zhu, Yin-Xing, Lin, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324502/
https://www.ncbi.nlm.nih.gov/pubmed/37424953
http://dx.doi.org/10.4252/wjsc.v15.i6.514
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author Yue, Miao
Guo, Ting
Nie, Deng-Yun
Zhu, Yin-Xing
Lin, Mei
author_facet Yue, Miao
Guo, Ting
Nie, Deng-Yun
Zhu, Yin-Xing
Lin, Mei
author_sort Yue, Miao
collection PubMed
description Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, proliferation, and differentiation potential. The elimination of CSCs is thus the key to cure cancer, and targeting CSCs provides a new method for tumor treatment. Due to the advantages of controlled sustained release, targeting and high biocompatibility, a variety of nanomaterials are used in the diagnosis and treatments targeting CSCs and promote the recognition and removal of tumor cells and CSCs. This article mainly reviews the research progress of nanotechnology in sorting CSCs and nanodrug delivery systems targeting CSCs. Furthermore, we identify the problems and future research directions of nanotechnology in CSC therapy. We hope that this review will provide guidance for the design of nanotechnology as a drug carrier so that it can be used in clinic for cancer therapy as soon as possible.
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spelling pubmed-103245022023-07-07 Advances of nanotechnology applied to cancer stem cells Yue, Miao Guo, Ting Nie, Deng-Yun Zhu, Yin-Xing Lin, Mei World J Stem Cells Review Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, proliferation, and differentiation potential. The elimination of CSCs is thus the key to cure cancer, and targeting CSCs provides a new method for tumor treatment. Due to the advantages of controlled sustained release, targeting and high biocompatibility, a variety of nanomaterials are used in the diagnosis and treatments targeting CSCs and promote the recognition and removal of tumor cells and CSCs. This article mainly reviews the research progress of nanotechnology in sorting CSCs and nanodrug delivery systems targeting CSCs. Furthermore, we identify the problems and future research directions of nanotechnology in CSC therapy. We hope that this review will provide guidance for the design of nanotechnology as a drug carrier so that it can be used in clinic for cancer therapy as soon as possible. Baishideng Publishing Group Inc 2023-06-26 2023-06-26 /pmc/articles/PMC10324502/ /pubmed/37424953 http://dx.doi.org/10.4252/wjsc.v15.i6.514 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Yue, Miao
Guo, Ting
Nie, Deng-Yun
Zhu, Yin-Xing
Lin, Mei
Advances of nanotechnology applied to cancer stem cells
title Advances of nanotechnology applied to cancer stem cells
title_full Advances of nanotechnology applied to cancer stem cells
title_fullStr Advances of nanotechnology applied to cancer stem cells
title_full_unstemmed Advances of nanotechnology applied to cancer stem cells
title_short Advances of nanotechnology applied to cancer stem cells
title_sort advances of nanotechnology applied to cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324502/
https://www.ncbi.nlm.nih.gov/pubmed/37424953
http://dx.doi.org/10.4252/wjsc.v15.i6.514
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