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Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324588/ https://www.ncbi.nlm.nih.gov/pubmed/37425199 http://dx.doi.org/10.5114/jcb.2023.127837 |
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author | Fionda, Bruno Placidi, Elisa Rosa, Enrico Lancellotta, Valentina Stimato, Gerardina De Angeli, Martina Ciardo, Francesco Giuseppe Cornacchione, Patrizia Siebert, Frank-Andre Tagliaferri, Luca Indovina, Luca |
author_facet | Fionda, Bruno Placidi, Elisa Rosa, Enrico Lancellotta, Valentina Stimato, Gerardina De Angeli, Martina Ciardo, Francesco Giuseppe Cornacchione, Patrizia Siebert, Frank-Andre Tagliaferri, Luca Indovina, Luca |
author_sort | Fionda, Bruno |
collection | PubMed |
description | Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, lesions thicker than 5 mm may be treated by contact IRT. The use of image guidance in defining the actual depth in treating NMSC to correctly identify clinical target volume (CTV) and prevent unnecessary toxicity is of paramount importance. The aim of the paper was to describe a multilayer arrangement of catheters to treat NMSC lesions thicker than 5 mm, thus proposing an example of dynamic intensity modulated IRT, using different catheter-to-skin distance of sources to reach the best CTV coverage and maximally reduce the excess of dose to the skin. |
format | Online Article Text |
id | pubmed-10324588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-103245882023-07-07 Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer Fionda, Bruno Placidi, Elisa Rosa, Enrico Lancellotta, Valentina Stimato, Gerardina De Angeli, Martina Ciardo, Francesco Giuseppe Cornacchione, Patrizia Siebert, Frank-Andre Tagliaferri, Luca Indovina, Luca J Contemp Brachytherapy Original Paper Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, lesions thicker than 5 mm may be treated by contact IRT. The use of image guidance in defining the actual depth in treating NMSC to correctly identify clinical target volume (CTV) and prevent unnecessary toxicity is of paramount importance. The aim of the paper was to describe a multilayer arrangement of catheters to treat NMSC lesions thicker than 5 mm, thus proposing an example of dynamic intensity modulated IRT, using different catheter-to-skin distance of sources to reach the best CTV coverage and maximally reduce the excess of dose to the skin. Termedia Publishing House 2023-06-01 2023-06 /pmc/articles/PMC10324588/ /pubmed/37425199 http://dx.doi.org/10.5114/jcb.2023.127837 Text en Copyright © 2023 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Fionda, Bruno Placidi, Elisa Rosa, Enrico Lancellotta, Valentina Stimato, Gerardina De Angeli, Martina Ciardo, Francesco Giuseppe Cornacchione, Patrizia Siebert, Frank-Andre Tagliaferri, Luca Indovina, Luca Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer |
title | Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer |
title_full | Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer |
title_fullStr | Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer |
title_full_unstemmed | Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer |
title_short | Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer |
title_sort | multilayer intensity modulated contact interventional radiotherapy (brachytherapy): stretching the therapeutic window in skin cancer |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324588/ https://www.ncbi.nlm.nih.gov/pubmed/37425199 http://dx.doi.org/10.5114/jcb.2023.127837 |
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