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Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer

Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut...

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Autores principales: Fionda, Bruno, Placidi, Elisa, Rosa, Enrico, Lancellotta, Valentina, Stimato, Gerardina, De Angeli, Martina, Ciardo, Francesco Giuseppe, Cornacchione, Patrizia, Siebert, Frank-Andre, Tagliaferri, Luca, Indovina, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324588/
https://www.ncbi.nlm.nih.gov/pubmed/37425199
http://dx.doi.org/10.5114/jcb.2023.127837
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author Fionda, Bruno
Placidi, Elisa
Rosa, Enrico
Lancellotta, Valentina
Stimato, Gerardina
De Angeli, Martina
Ciardo, Francesco Giuseppe
Cornacchione, Patrizia
Siebert, Frank-Andre
Tagliaferri, Luca
Indovina, Luca
author_facet Fionda, Bruno
Placidi, Elisa
Rosa, Enrico
Lancellotta, Valentina
Stimato, Gerardina
De Angeli, Martina
Ciardo, Francesco Giuseppe
Cornacchione, Patrizia
Siebert, Frank-Andre
Tagliaferri, Luca
Indovina, Luca
author_sort Fionda, Bruno
collection PubMed
description Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, lesions thicker than 5 mm may be treated by contact IRT. The use of image guidance in defining the actual depth in treating NMSC to correctly identify clinical target volume (CTV) and prevent unnecessary toxicity is of paramount importance. The aim of the paper was to describe a multilayer arrangement of catheters to treat NMSC lesions thicker than 5 mm, thus proposing an example of dynamic intensity modulated IRT, using different catheter-to-skin distance of sources to reach the best CTV coverage and maximally reduce the excess of dose to the skin.
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spelling pubmed-103245882023-07-07 Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer Fionda, Bruno Placidi, Elisa Rosa, Enrico Lancellotta, Valentina Stimato, Gerardina De Angeli, Martina Ciardo, Francesco Giuseppe Cornacchione, Patrizia Siebert, Frank-Andre Tagliaferri, Luca Indovina, Luca J Contemp Brachytherapy Original Paper Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, lesions thicker than 5 mm may be treated by contact IRT. The use of image guidance in defining the actual depth in treating NMSC to correctly identify clinical target volume (CTV) and prevent unnecessary toxicity is of paramount importance. The aim of the paper was to describe a multilayer arrangement of catheters to treat NMSC lesions thicker than 5 mm, thus proposing an example of dynamic intensity modulated IRT, using different catheter-to-skin distance of sources to reach the best CTV coverage and maximally reduce the excess of dose to the skin. Termedia Publishing House 2023-06-01 2023-06 /pmc/articles/PMC10324588/ /pubmed/37425199 http://dx.doi.org/10.5114/jcb.2023.127837 Text en Copyright © 2023 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Fionda, Bruno
Placidi, Elisa
Rosa, Enrico
Lancellotta, Valentina
Stimato, Gerardina
De Angeli, Martina
Ciardo, Francesco Giuseppe
Cornacchione, Patrizia
Siebert, Frank-Andre
Tagliaferri, Luca
Indovina, Luca
Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
title Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
title_full Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
title_fullStr Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
title_full_unstemmed Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
title_short Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer
title_sort multilayer intensity modulated contact interventional radiotherapy (brachytherapy): stretching the therapeutic window in skin cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324588/
https://www.ncbi.nlm.nih.gov/pubmed/37425199
http://dx.doi.org/10.5114/jcb.2023.127837
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